Visual perceptual skills and visual motor integration in children and adolescents after allogeneic hematopoietic stem cell transplantation |
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| Authors: | Kristina Teär Fahnehjelm Alba Lucia Törnquist Monica Olsson Jacek Winiarski Ulla Ek |
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| Affiliation: | 1. Department of Clinical Neuroscience, Karolinska Institutet, St. Erik Eye Hospital, Stockholm, Sweden;2. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;3. Department of Paediatrics, Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, Sweden;4. Department of Clintec, Karolinska Institutet, Stockholm, Sweden;5. Department of Special Education, Stockholm University, Stockholm, Sweden |
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| Abstract: | The aim of the study was to study visual acuity, visual perceptual, and VMI skills in patients after HSCT in childhood. Tests of visual perceptual skills, VMI, and visual acuity were performed in 102 children/adolescents (age range 4.3‐20.9 years). Mean time from HSCT to testing was 6.0 years (0.9‐17.5 years). Visual acuity was median 1.0 decimal (range 0.16‐1.6). Visual perceptual skills (memory, form constancy, visual sequential memory) and VMI were low compared to age‐equivalent normative data with, respectively, 36%, 45%, 60%, and 46% of all patients performing below the 25 percentile. All patients performed significantly lower than the 50 percentile in the reference material in visual sequential memory, P < .001 (boys P < .001 and girls P < .05). All patients also performed significantly lower than the 50 percentile in VMI (P < .01) (boys P < .05). Pretransplant conditioning regimen did not affect outcome if the results were corrected for age at HSCT. Visual perceptual skill problems and VMI problems frequently occur in patients after HSCT in childhood. Age at HSCT and original diagnosis influence the outcome. Neuropsychological assessment including visual perception is recommended in children after HSCT. |
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| Keywords: | adverse effects hematopoietic stem cell transplantation |
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