Ribosomal movement impeded at a pseudoknot required for frameshifting. |
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| Authors: | C Tu T H Tzeng J A Bruenn |
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| Affiliation: | Department of Biological Sciences, State University of New York, Buffalo 14260. |
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| Abstract: | ![]()
Translational frameshifting sometimes occurs when ribosomes encounter a "shift" site preceding a region of unusual secondary structure, which in at least three cases is known to be a pseudoknot. We provide evidence that ribosomes have a decreased rate of movement through a pseudoknot required for frameshifting. These paused ribosomes are directly situated over the shift sequence. Ribosomal pausing appears to be necessary but not sufficient for frameshifting. |
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