| 2型糖尿病鼠类模型的研究进展 |
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| 引用本文： | 高秀莹,周迎生.2型糖尿病鼠类模型的研究进展[J].实验动物与比较医学,2014,22(4):71-76. |
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| 作者姓名： | 高秀莹 周迎生 |
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| 作者单位： | 首都医科大学附属北京安贞医院内分泌代谢科, 北京市心肺血管疾病研究所, 北京 100029;首都医科大学附属北京安贞医院内分泌代谢科, 北京市心肺血管疾病研究所, 北京 100029 |
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| 基金项目： | 国家自然科学基金（81041024）；教育部留学回国基金（2012-940）；人事部留学回国基金（2010-412）；北京市科委科研基金（Z13110200400000）；北京市学科带头人基金（2013-2-006）。 |
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| 摘 要： | 小鼠、大鼠糖尿病模型对基础与临床防治研究十分重要，不同的研究目标对应不同的动物模型载体。本文就目前常用的2型糖尿病鼠类模型的构建、主要疾病特征及应用等进行评述，为研究者了解、选择适合的动物模型提供参考。
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| 关 键 词： | 2型糖尿病 动物模型 鼠类 |
| 收稿时间： | 2014/6/3 0:00:00 |
| 修稿时间： | 2014/2/18 0:00:00 |
Review of mouse and rat models for type 2 diabetes mellitus |
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| GAO Xiu-ying and ZHOU Ying-sheng.Review of mouse and rat models for type 2 diabetes mellitus[J].Laboratory Animal and Comparative Medicine,2014,22(4):71-76. |
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| Authors: | GAO Xiu-ying and ZHOU Ying-sheng |
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| Affiliation: | Endocrinology & Metabolism Department Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing Institute of Heart, Lung, and Vascular Diseases, Beijing 100029, China;Endocrinology & Metabolism Department Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing Institute of Heart, Lung, and Vascular Diseases, Beijing 100029, China |
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| Abstract: | Mouse and rat models of type 2 diabetes mellitus play a key role in basic and clinical translational studies. Different animal models should match the determined investigational objects and methods. In this review, the establishments and diabetes-specific changes of various animal models were described, which will be helpful for better use of animal models in research of diabetes mellitus. |
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| Keywords: | Type 2 diabetes Animal model Mouse Rat |
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