| 慢性肾脏疾病患者血清尿酸水平与动脉硬化的相关性分析 |
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| 引用本文： | 王晓红1,匡璐2,曾冬冬1,张瑛1,刘爱群1,邹和群1. 慢性肾脏疾病患者血清尿酸水平与动脉硬化的相关性分析[J]. 现代预防医学, 2015, 0(19): 3615-3617 |
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| 作者姓名： | 王晓红1 匡璐2 曾冬冬1 张瑛1 刘爱群1 邹和群1 |
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| 作者单位： | 1.南方医科大学第三附属医院肾内科，广东 广州 510000；2.南方医科大学第三附属医院泌尿外科，广东 广州 510000 |
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| 摘 要： | 摘要:目的 探讨慢性肾脏疾病（CKD）患者血清尿酸水平与动脉硬化的相关性。方法 选取诊断为CKD患者900例，按照血清尿酸水平分为4组（即CKD组1～4），同时选取健康志愿者200名作为对照组。通过超声检查、眼底动脉检查和CT扫描确定动脉硬化患者例数。对各组间动脉硬化患病率、血清尿酸水平和动脉硬化的相关性进行统计学分析。结果 CKD组1、CKD组2、CKD组3和CKD组4的组间动脉硬化的患病率差异有统计学意义（χ2＝20.27，P＜0.05）。CKD组1和CKD组3比较差异有统计学意义（χ2＝11.11，P＜0.05）；CKD组1和CKD组4比较差异有统计学意义（χ2＝16.64，P＜0.05）；CKD组2与CKD组4比较差异有统计学意义（χ2＝6.42，P＜0.05）。与对照组相比，仅有CKD组3和CKD组4与对照组患病率相比差异有统计学意义（CKD组3和对照组相比:χ2＝5.43，P＜0.05；CKD组4和对照组相比:χ2＝9.13，P＜0.05）。男性患者动脉硬化的患病率为60.69%（281/463），女性患者动脉硬化患病率为37.76%（165/437），差异有统计学意义（χ2＝16.12，P＜0.05）。结论 随着慢性肾脏疾病患者血清尿酸水平的增高，动脉硬化患病率增高；慢性肾脏疾病患者血清尿酸水平与动脉硬化呈正相关。
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| 关 键 词： | 关键词:肾功能不全 慢性 尿酸 动脉粥样硬化 |
Correlation between serum uric acid level and atherosclerosis |
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| WANG Xiao-hong,KUANG Lu,ZENG Dong-dong,ZHANG Ying,LIU Ai-qun,ZOU He-qun. Correlation between serum uric acid level and atherosclerosis[J]. Modern Preventive Medicine, 2015, 0(19): 3615-3617 |
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| Authors: | WANG Xiao-hong KUANG Lu ZENG Dong-dong ZHANG Ying LIU Ai-qun ZOU He-qun |
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| Affiliation: | The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510000, China |
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| Abstract: | Abstract: Objective To explore the correlation between serum uric acid level and atherosclerosis on patients with chronic kidney disease (CKD). Methods Totally 900 patients of CKD (case group) and 200 healthy volunteers (control group) were enrolled. According to serum uric acid levels, the patients in case group were divided into 4 subgroups. The artery sclerosis were determined by ultrasound examination, fundus examination and CT scan. The differences of incidence of atherosclerosis in all groups, and the correlation between the serum uric acid level and atherosclerosis were analyzed. Results The differences for prevalence of arteriosclerosis between group 1 to 4 were statistically significant (χ2=20.27, P<0.05). The prevalence of arteriosclerosis differences between group 1 and group 3 was statistically significant (χ2=11.11, P<0.05). Group 1 and group 4 CKD comparative difference was statistically significant (χ2=16.64, P<0.05). CKD comparative difference between group 2 and group 4 was statistically significant (χ2=6.42, P<0.05). Group 3 compared with control group: χ2=5.43, P<0.05; group 4 compared with control group: χ2=9.13, P<0.05. In male patients with arteriosclerosis, the prevalence rate was 60.69% (281/463), while in females it was 37.76% (165/437), and the difference was statistically significant (χ2=16.12, P<0.05). Conclusion With increasing serum uric acid levels in the patients with CKD, the incidence of atherosclerosis increased. Serum uric acid level in CKD patients was positively correlated with the atherosclerosis. |
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| Keywords: | Keywords: Renal insufficiency chronic Uric acid Atherosclerosis |
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