| MACC1及c-met在前列腺癌中的表达及临床意义 |
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| 引用本文： | 刘洪新1,李先佳2,沈杰1,沈俭1,包卫东1,陈建华1. MACC1及c-met在前列腺癌中的表达及临床意义[J]. 现代预防医学, 2015, 0(19): 3611-3614 |
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| 作者姓名： | 刘洪新1 李先佳2 沈杰1 沈俭1 包卫东1 陈建华1 |
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| 作者单位： | 1.上海交通大学医学院附属新华医院崇明分院泌尿外科，上海 202150；2.漯河医学高等专科学校基础部，河南 漯河 462002 |
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| 摘 要： | 摘要:目的 探讨前列腺癌组织中结肠癌转移相关基因1（MACC1）及肝细胞生长因子受体（c-met）蛋白的表达及临床意义。方法 应用免疫组化方法检测76例前列腺癌组织和16例前列腺增生组织中MACC1及c-met蛋白的表达情况。结果 前列腺癌组织中MACC1蛋白阳性率为59.2%，显著高于前列腺增生组织（18.8%），（χ2＝8.671，P＝0.003）；c-met蛋白在前列腺癌组织中阳性率64.5%，显著高于前列腺增生组织（31.2%），（χ2＝6.018，P＝0.014）；随访结果提示MACC1和c-met阳性患者生存率显著低于阴性患者，（χ2＝5.480，P＝0.019；χ2＝14.826，P＜0.001）；MACC1与c-met蛋白呈正相关。结论 MACC1及c-met蛋白表达增高与前列腺癌的临床分期、病理分级、患者预后密切相关。联合检测MACC1及c-met蛋白可以作为反映前列腺癌的生物学行为的客观指标，有助于判断患者预后。
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| 关 键 词： | 关键词:前列腺癌 结肠癌转移相关基因1 免疫组织化学 |
Expression of MACC1 and C-met in human prostatic cancer and its clinical significance |
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| LIU Hong-xin,LI Xian-jia,SHEN Jie,SHEN Jian,BAO Wei-dong,CHEN Jian-hua. Expression of MACC1 and C-met in human prostatic cancer and its clinical significance[J]. Modern Preventive Medicine, 2015, 0(19): 3611-3614 |
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| Authors: | LIU Hong-xin LI Xian-jia SHEN Jie SHEN Jian BAO Wei-dong CHEN Jian-hua |
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| Affiliation: | Department of Urology, Medicine Chongming Branch of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, Chongming, Shanghai 202150, China |
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| Abstract: | Abstract: Objective To study expression of MACC1 (metastasis-associated in colon cancer-1) and c-met in prostatic cancer, and explore their clinical pathological significance. Methods The expression of MACC1 and c-met protein was detected by immunohistochemistry in 76 cases of prostatic cancer and 16 cases of hyperplasia of prostate. Results MACC1 protein positive rate was 59.2% in prostatic cancer, which was significantly higher than that of the hyperplasia of prostate (18.8%), (χ2=8.671, P=0.003). The positive rate of c-met protein in prostatic cancer was 64.5%, which was significantly higher than hyperplasia of prostate (31.2%), (χ2=6.018, P=0.014). The follow-up results showed that positive patients survival rate of MACC1 and c-met were significantly lower than that of negative patients, (χ2=5.480, P=0.019; χ2=14.826, P<0.001). MACC1 was positively correlated with c-Met. Conclusion MACC1 and c-met protein overexpression were closely related to clinical stage, pathological grade and prognosis of prostatic cancer. MACC1 and c-met were positive correlated. Combined detection of MACC1 and c-met can reflect the biologic behavior of prostatic cancer and contribute to judgment the prognosis of the patients. |
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| Keywords: | Keywords: Prostatic cancer Metastasis-associated in colon cancer-1 Immunohistochemisty |
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