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| 高尿酸血症与H型高血压之间的年龄依赖性 | |
| 引用本文： | 张丹丹1,2,3,4,洪秀琴2,3,4,王佳2,3,4,李璟2,3,4,曾丹2,3,4,陈建1,2. 高尿酸血症与H型高血压之间的年龄依赖性[J]. 现代预防医学, 2020, 0(2): 371-375 |
| 作者姓名： | 张丹丹1 2 3 4 洪秀琴2 3 4 王佳2 3 4 李璟2 3 4 曾丹2 3 4 陈建1 2 |
| 作者单位： | 1.南华大学 公共卫生学院，湖南 衡阳 421001；2.湖南省人民医院，湖南 长沙 410005；3.湖南省分子流行病学重点实验室，湖南 长沙 410005；4.湖南师范大学转化医学研究所流行病学研究室，湖南 长沙 410005 |
| 摘 要： | 目的 探讨湖南省社区居民高尿酸血症与H型高血压之间年龄依赖的关联性，为H型高血压防治提供科学依据。方法 以整群抽样方法调查湖南省6个地区30 ~90岁的常住社区高血压居民，通过问卷调查、实验室检测血液生化指标及logistic回归分析统计学方法分析不同年龄层高尿酸血症与H型高血压之间的相关性。结果 本研究纳入1 395名研究对象，其中H型高血压86.6%。单因素分析结果显示，≤60岁人群，非高尿酸血症与高尿酸血症人群间H型高血压患病率、教育程度、BMI、ALT、STP、Cr、BUG、TG、VLDL的差异具有统计学意义（均P＜0.05）；＞60岁人群，非高尿酸血症与高尿酸血症人群之间ALT、STP、Cr、BUG、TG、TC、VLDL差异具有统计学意义（均P＜0.05）。logistic回归分析:伴有高尿酸血症使H型高血压事件的发生风险显著增加（P = 0.001, OR = 2.24, 95%CI = 1.37～3.67）。年龄分层，仅≤60岁人群，高尿酸血症是H型高血压事件的的独立危险因素（P = 0.007, OR = 2.36, 95%CI = 1.26～4.41）。交互作用分析结果显示:≤60岁，尿酸与性别、总蛋白、VLDL的交互作用影响H型高血压（女性:P = 0.040, OR = 0.826, 95%CI = 0.69～0.99；STP:P = 0.028, OR = 1.007, 95%CI = 1.001～1.012；VLDL: P = 0.011, OR = 1.183, 95%CI = 1.04～1.35 ）；＞60岁，尿酸仅与VLDL存在交互作用影响H型高血压（P＜0.001, OR = 1.698, 95%CI = 1.262～2.285）。结论 ≤60岁人群，高尿酸血症是H型高血压的独立危险因素。 |
| 关 键 词： | H型高血压 普通型高血压 同型半胱氨酸 高尿酸血症 |
Correlation between hyperuricemia and type H hypertension in different age groups |
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| ZHANG Dan-dan,HONG Xiu-qin,WANG Jia,LI Jing,ZENG Dan,CHEN Jian. Correlation between hyperuricemia and type H hypertension in different age groups[J]. Modern Preventive Medicine, 2020, 0(2): 371-375 | |
| Authors: | ZHANG Dan-dan HONG Xiu-qin WANG Jia LI Jing ZENG Dan CHEN Jian |
| Affiliation: | *School of Public Health, University of South China, Hengyang Hunan 421001, China |
| Abstract: | Objective The aim of this study was to explore the age-related association between hyperuricemia and H-type hypertension in community hypertension patients in Hunan province, and to provide evidence for prevention and treatment of H-type hypertension. Methods Cluster sampling method was used to investigate hypertension residents in the resident communities from 30 to 90 years old in 6 districts of Hunan province. Through questionnaires, laboratory blood biochemical indicators and logistic regression analysis, the correlation between hyperuricemia and H-type hypertension in different age groups was analyzed. Results A total of 1395 subjects were included in the study, of which H-type hypertension was 86.6%.Stratification of age, compared with non-hyperuricemia, the differences in marital status, education level, ALT, Cre, UA, TG,TC, VLDL and hcy were statistically significant(P<0.05 for all) in ≤60-year-old population. The differences between ALT,STP, Cre, BUG, TG, TC, VLDL between non-hyperuricemia and hyperuricemia population were statistically significant(P<0.05 for all) in > 60-year-old population. Logistic regression analysis showed: the risk of hyperuricemia with H-type hypertension was significantly increased(P=0.001, OR=2.24, 95% CI=1.37-3.67). However, only for those ≤ 60 years old,hyperuricemia was an independent risk factor for H-type hypertension events(P=0.007, OR=2.36, 95% CI=1.26-4.41). The results of interaction analysis showed that: for those ≤60 years old, the interaction of uric acid with gender, total protein and VLDL affected H-type hypertension(Female: P=0.040, OR=0.826, 95% CI=0.69-0.99; STP: P=0.028, OR=1.007, 95% CI=1.001-1.012; VLDL: P=0.011, OR=1.183, 95% CI=1.04-1.35). For those >60 years old, uric acid only interacted with VLDL to affect H-type hypertension(P <0.0001, OR =1.698, 95% CI =1.262-2.285). Conclusion Hyperuricemia(HUA) was an independent risk factor for H-type hypertension, but this rule only existed in people under the age of 60 years. |
| Keywords: | H-type hypertension Common hypertension Homocysteine Hyperuricemia |
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