| 反流性食管炎与幽门螺杆菌感染相关性的Meta分析 |
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| 引用本文： | 雷婷婷1,陈玲2. 反流性食管炎与幽门螺杆菌感染相关性的Meta分析[J]. 现代预防医学, 2020, 0(13): 2480-2486 |
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| 作者姓名： | 雷婷婷1 陈玲2 |
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| 作者单位： | 1.重庆医科大学第一临床学院,重庆 400331;2.重庆医科大学实验教学管理中心,重庆 400331 |
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| 摘 要： | 目的 用Meta分析法探讨幽门螺杆菌(Hp)与反流性食管炎(RE)的关系。方法 检索中外文电子数据库,按纳入排除标准筛选文献,利用Stata 12.0行Meta分析。结果 纳入文献23篇,RE患者8754人。(1)RE发生与Hp感染相关（I2=90.4%;OR=0.62;95%CI=0.47~0.83;P=0.001）。(2)亚组分析结果:亚洲地区RE发生与Hp相关（OR=0.60;95%CI=0.44~0.82;P<0.001）,欧洲地区不相关（OR=0.86;95%CI=0.50~1.46;p=0.645);对照组为正常、NERD或其他消化道疾病时,结果均显示RE发生与Hp感染相关（OR=0.588,95%CI=0.396~0.874,P<0.001;OR=0.947,95%CI=0.380~2.360,P=0.024;OR=0.401,95%CI=0.466~0.876,P=0.041）(3)RE发生与性别无关（I2=94.9%;OR= 1.325;95%CI= 0.876~2.003;P=0.183）。(4)RE分级与Hp感染无关（OR=1.59;95%CI=0.94~2.69;P=0.083)。结论 反流性食管炎的发生与幽门螺杆菌感染相关,与性别无关。不同地区反流性食管炎与幽门螺杆菌感染的相关性不同,反流性食管炎病情程度不受幽门螺杆菌影响。
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| 关 键 词： | 反流性食管炎 幽门螺杆菌 胃食管反流病 Meta分析 |
The correlation of reflux esophagitis and Helicobacter pylori infection: a meta-analysis |
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| LEI Ting-ting,CHEN Ling. The correlation of reflux esophagitis and Helicobacter pylori infection: a meta-analysis[J]. Modern Preventive Medicine, 2020, 0(13): 2480-2486 |
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| Authors: | LEI Ting-ting CHEN Ling |
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| Affiliation: | *The First Clinical College of Chongqing Medical University, Chongqing 400331, China |
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| Abstract: | To study the relativity of Reflux esophagitis ( ＲE) and Helicobacter pylori( ( Hp) ) infection by using meta － analysis. Methods Comprehensive search strategy was conducted in both Chinese and foreign databases to retrieve original studies according to the inclusion and exclusion criteria. The outcomes were analyzed through meta － analysis by using Stata12. 0. Results 23 studies were included,which involved 8754 patients with reflux esophagitis. ( 1) The infection of Hp is associated with ＲE( I2 = 90. 4% ; OＲ = 0. 62; 95% CI = 0. 47 － 0. 83; P = 0. 001) . ( 2) Subgroup analysis based on study location,the occurrence of ＲE was related to the infection of Hp in Asia( OＲ = 0. 60; 95% CI = 0. 44 － 0. 82; P ＜ 0. 001) ,but not in Europe( OＲ = 0. 94; 95% CI = 0. 48 － 1. 82; P = 0. 077) . When selecting normal people,patients with NEＲD or other digestive diseases as control,all three types showed that Hp can affect the morbidity of ＲE( OＲ = 0. 588; 95% CI = 0. 396 －0. 874; P ＜ 0. 001; OＲ = 0. 947; 95% CI = 0. 380 － 2. 360; P = 0. 024; OＲ = 0. 401; 95% CI = 0. 466 － 0. 876; P = 0. 041) .( 3) Gender is not associated with the morbidity of ＲE( OＲ = 1. 433; 95% CI = 0. 82 － 2. 45; P = 0. 204) . ( 4) There is no correlation between the degree of ＲE and Hp infection ( OＲ = 1. 59; 95% CI = 0. 94 － 2. 69; P = 0. 083 ) . Conclusion The occurrence of Reflux esophagitis is associated with Helicobacter pylori infection,but not with gender. The correlation between reflux esophagitis and Helicobacter pylori infection is different in different areas,and these verity of reflux esophagitis is not affected by Helicobacter pylori. |
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| Keywords: | Reflux esophagitis Helicobacter pylori Gastroesophageal reflux disease Meta － analysis |
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