Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase |
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| Authors: | Kahn Jennifer Nielsen Garcia-Effron Guillermo Hsu Ming-Jo Park Steven Marr Kieren A Perlin David S |
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| Affiliation: | PHRI, Newark, NJ 07103, USA. |
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| Abstract: | ![]()
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655-->Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp. |
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