Plasmodium chabaudi malaria: protective immunization with surface membranes of infected erythrocytes. |
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| Authors: | F Wunderlich H H Brenner M Helwig |
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| Affiliation: | Division of Parasitology, University of Duesseldorf, Federal Republic of Germany. |
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| Abstract: | Plasmodium chabaudi-susceptible NMRI and B10.A mice were vaccinated with host cell plasma membranes isolated from P. chabaudi-infected erythrocytes. Most of the mice were protected from the lethal consequences of challenge with the homologous parasite, although protection was unassociated with a reduction in the course or peak of parasitemia. Vaccination also induced the production of antibodies against Pc90, which is the immunodominant protein expressed by parasites in host cell plasma membranes. |
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