EBM/11 reactivity in malignant histiocytosis. |
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| Authors: | P M Kelly M McGovern K C Gatter J M Theaker J O McGee |
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| Affiliation: | University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital. |
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| Abstract: | A patient presented initially with a testicular mass, which on biopsy had morphological features consistent with malignant histiocytosis. The tumour cells labelled strongly with EBM/11, a murine monoclonal antibody with high specificity for cells of the human mononuclear phagocyte system. Subsequent clinical and laboratory studies confirmed the diagnosis. As poorly differentiated tumour cells reacted with EBM/11, this antibody may be useful in positively identifying malignant tumours with histiocytic differentiation from malignancies of other types where morphological detail alone is inconclusive in tumour classification. |
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