| 化痰祛湿疏肝方联合辛伐他汀治疗非酒精性脂肪性肝病痰湿内阻证患者临床疗效研究* |
| |
| 引用本文： | 李亚文,周军.化痰祛湿疏肝方联合辛伐他汀治疗非酒精性脂肪性肝病痰湿内阻证患者临床疗效研究*[J].实用肝脏病杂志,2022,25(4):526-529. |
| |
| 作者姓名： | 李亚文 周军 |
| |
| 作者单位： | 200431 上海市复旦大学附属华山北院宝山分院/仁和医院中医科(李亚文);上海中医药大学附属上海市中西医结合医院重症医学科(周军) |
| |
| 基金项目： | *上海市科技计划项目(编号:20TR122362) |
| |
| 摘 要： | 目的 观察应用化痰祛湿疏肝方联合辛伐他汀治疗非酒精性脂肪性肝病(NAFLD)痰湿内阻证患者的临床疗效。方法 2020年2月～2022年1月我院诊治的符合中医痰湿内阻证的68例NAFLD患者,其中33例接受辛伐他汀治疗,另35例在上述治疗的基础上联合化痰祛湿疏肝方治疗,两组均治疗观察12 w。采用硫化巴比妥酸法和氧化酶法检测血清丙二醛(MDA)和超氧化物歧化酶(SOD)水平,使用彩色多普勒超声检测肝脏脂肪含量(LFC)。结果 在治疗结束时,中西药联合治疗组临床有效率为94.3%,显著高于辛伐他汀治疗组的75.8%(P<0.05);中西药联合治疗组右胁胀闷、周身困重、大便粘滞、倦怠无力和脘腹胀满的中医症候积分分别为(1.4±0.5)分、(0.9±0.2)分、(0.8±0.2)分、(1.2±0.4)分和(1.5±0.3)分,显著低于辛伐他汀治疗组分别为(2.8±0.7)分、(2.1±0.3)分、(1.5±0.4)分、(2.1±0.6)分和(2.4±0.6)分,P＜0.05];中西药联合治疗组肝功能和血清指标改善显著优于辛伐他汀治疗组(P＜0.05);中西药联合治疗组血清MDA和LFC分别为(7.5±1.3)μmol/L和(6.5±0.9)%,均显著低于辛伐他汀治疗组分别为(11.4±1.8)μmol/L和(7.9±1.3)%,P＜0.05],而血清SOD水平为(80.4±7.8)U/L,显著高于辛伐他汀治疗组(66.3±7.2)U/L,P＜0.05]。结论 应用化痰祛湿疏肝方联合辛伐他汀治疗非酒精性脂肪性肝病痰湿内阻证患者短期疗效显著,可改善肝功能和脂质代谢,降低肝脏脂肪含量。
|
| 关 键 词： | 非酒精性脂肪性肝病 化痰祛湿疏肝方 辛伐他汀 肝脏脂肪含量 治疗 |
| 收稿时间： | 2022-04-18 |
Clinical efficacy of Huatan Qushi Shugan decoction and simvastatin combination in the treatment of patients with non-alcoholic fatty liver disease |
| |
| Li Yawen,Zhou Jun.Clinical efficacy of Huatan Qushi Shugan decoction and simvastatin combination in the treatment of patients with non-alcoholic fatty liver disease[J].Journal of Clinical Hepatology,2022,25(4):526-529. |
| |
| Authors: | Li Yawen Zhou Jun |
| |
| Affiliation: | Department of Chinese Traditional Medicine, Renhe Hospital, Huashan North Hospital Baoshan Branch Affiliated to Fudan University,Shanghai 200431,China |
| |
| Abstract: | Objective The aim of this study was to observe the clinical efficacy of Huatan Qushi Shugan decoction, herbal medicines, and simvastatin combination in the treatment of patients with non-alcoholic fatty liver disease (NAFLD). Methods 68 patients with NAFLD with a special traditional Chinese medicine (TCM) type were encountered in our hospital between February 2020 and January 2022, and among them, 33 cases in control group received simvastatin therapy at base of routine diet and exercise guidance, and the other 35 patients received Huatan Qushi Shugan decoction at the base of above management in the control. The regimen lasted for 12 weeks. Serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were detected by thiobarbituric acid and oxidase method, and the liver fat content (LFC) was measured by color Doppler ultrasonography. Results The clinical effective rate as defined by comprehensive TCM judgement in patients with simvastatin and herbal medicine combination therapy was 94.3%, significantly higher than 75.8% in the control (P<0.05); the scores of TCM symptoms, such as distension in right hypochondrium, heavy feeling the whole body, sticky stool, lassitude and weakness and abdominal distention were (1.4±0.5), (0.9±0.2), (0.8±0.2), (1.2±0.4) and (1.5±0.3), significantly lower than (2.8±0.7), (2.1±0.3), (1.5±0.4), (2.1±0.6) and (2.4±0.6), respectively, P<0.05] in the control group; the improvement of liver function tests and blood fat were greatly superior to in the control; serum MDA and LFC were (7.5±1.3) μmol/L and (6.5±0.9)%, significantly lower than (11.4±1.8) μmol/L and (7.9±1.3)%, P<0.05], while serum SOD level was (80.4±7.8) U/L, significantly higher than (66.3±7.2) U/L, P<0.05] in the control group. Conclusion The combination of herbal medicine and simvastatin has an obvious short-term efficacy in the treatment of patients with NAFLD with special TCM syndrome, which could improve the liver function tests and lipid metabolism, and needs further investigation. |
| |
| Keywords: | Non-alcoholic fatty liver disease Huatan Qushi Shugan decoction Herbal medicines Simvastatin Liver fat content Therapy |
|
| 点击此处可从《实用肝脏病杂志》浏览原始摘要信息 |
|
点击此处可从《实用肝脏病杂志》下载全文 |
|
