Design and antileishmanial activity of amphotericin B-loaded stable ionic amphiphile biovector formulations |
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| Authors: | Loiseau P M Imbertie L Bories C Betbeder D De Miguel I |
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| Affiliation: | LBCOP, UPRES 398-IFR 75, Faculté de Pharmacie, Université de Paris XI, 92290 Chatenay-Malabry Cedex, France. philippe.loiseau@cep.u-psud.fr |
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| Abstract: | ![]()
A new delivery system, Ionic Amphiphilic Biovector (ABV), comprised of anionic lipids (dipalmitoyl phosphatidyl glycerol) included in a cationic cross-linked polysaccharide matrix was used as a reservoir for amphotericin B (AmB). Two ABV formulations exhibited an in vitro and in vivo efficacy similar to commercial AmBisome against Leishmania donovani-infected mice. The higher stability of these ABV formulations indicates their potential for further development and applications. |
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