Relationship of Serogroups of Neisseria meningitidis II. R Variants of Neisseria meningitidis |
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| Authors: | Leonard F. Devine Solon L. Rhode III Cline R. Hagerman |
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| Affiliation: | aBacteriology Division and Epidemiology Division, Naval Medical Research Unit No. 4, Great Lakes, Illinois 60088 |
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| Abstract: | Meningococci isolated in primary cultures from nasopharyngeal carriers occasionally consisted of mixtures of smooth (S) and rough (R) strains. The R strains were separated from the S strains and their morphological and serological characteristics were studied. Some of these R strains reverted spontaneously to S strains which subsequently produced group-specific polysaccharide. Several R strains, grown in the presence of deoxyribonucleic acid from either an R strain of known parentage or an S strain, formed recombinants with serological group specificity. |
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