Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran |
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| Authors: | Salomeh Fouladi1Minoo Adib1Mansoor Salehi2Hadi Karimzadeh3Zahra Bakhshiani1Vajiheh Ostadi1 |
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| Affiliation: | 1Department of Immunology2Department of Genetics and Molecular Biology3Department of Rheumatology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: | Background: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. Objective: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). Methods: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLAB* 27 subtypes were determined by PCR-SSP. Results: Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls. Conclusion: Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnicgroup studies. |
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| Keywords: | Ankylosing Spondylitis HLA-B27 PCR |
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