| 孕妇分娩年龄和初潮年龄间隔年数与大于胎龄儿的相关性 |
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| 引用本文： | 廖倩, 梁军, 黄东萍, 刘顺, 郭晓婧, 仇小强. 孕妇分娩年龄和初潮年龄间隔年数与大于胎龄儿的相关性[J]. 中华疾病控制杂志, 2022, 26(3): 297-301. doi: 10.16462/j.cnki.zhjbkz.2022.03.010 |
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| 作者姓名： | 廖倩 梁军 黄东萍 刘顺 郭晓婧 仇小强 |
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| 作者单位： | 1.530021 南宁，广西医科大学公共卫生学院流行病学教研室;;2.530021 南宁，广西医科大学公共卫生学院卫生化学教研室;;3.530021 南宁，广西医科大学公共卫生学院儿少卫生与妇幼保健教研室 |
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| 基金项目： | 国家自然科学基金;广西重点研发计划 |
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| 摘 要： | 目的 探讨孕妇分娩年龄和初潮年龄间隔年数与大于胎龄儿(large for gestational age, LGA)的相关性。方法 选取2015年6月—2018年4月在广西壮族自治区百色市5个县孕早期建卡产检2 032名孕妇为研究对象。分析孕妇间隔年龄与LGA发生的相关性，接收者操作特征(receiver operating characteristic, ROC)曲线分析孕妇间隔年龄在预测LGA发生中的作用。结果 队列随访至2 032名孕妇分娩，其中发生LGA 67例，发生率为3.3%。LGA组孕妇分娩年龄、间隔年龄和BMI较非LGA组大(均有P < 0.05)。相关性分析中，校正混杂因素后，孕妇间隔年龄与出生体重无相关(P=0.178)，但间隔年龄≥30岁的孕妇LGA发生风险是间隔年龄 < 10岁的29.214倍(P=0.018)。ROC曲线分析显示，孕妇间隔年龄预测总体、分娩女婴的AUC分别为0.585、0.644，孕妇间隔年龄预测LGA的最佳截断点均为13岁。结论 孕妇分娩年龄和初潮年龄间隔年数与LGA发生有关，间隔年数越大则LGA发生风险越大。分娩年龄和初潮年龄间隔在女婴LGA发生预测中效果更好。
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| 关 键 词： | 大于胎龄儿 初潮年龄 分娩年龄 出生队列 妊娠结局 |
| 收稿时间： | 2021-03-27 |
| 修稿时间： | 2021-08-17 |
Correlation between the infants of large for gestational age and the age interval of delivery age and menarche age |
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| LIAO Qian, LIANG Jun, HUANG Dong-ping, LIU Shun, GUO Xiao-jing, QIU Xiao-qiang. Correlation between the infants of large for gestational age and the age interval of delivery age and menarche age[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(3): 297-301. doi: 10.16462/j.cnki.zhjbkz.2022.03.010 |
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| Authors: | LIAO Qian LIANG Jun HUANG Dong-ping LIU Shun GUO Xiao-jing QIU Xiao-qiang |
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| Affiliation: | 1. Department of Epidemiology, School of public health, Guangxi Medical University, Nanning 530021, China;;2. Department of Sanitary Chemistry, School of public health, Guangxi Medical University, Nanning 530021, China;;3. Department of Maternal, Child and Adolescent Health, School of public health, Guangxi Medical University, Nanning 530021, China |
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| Abstract: | Objective To explore the correlation between the infants of large for gestational age(LGA) and the age interval of delivery age and menarche age. Methods A total of 2 032 pregnant women were enrolled from June 2015 to April 2018 in the five Maternal and Child Health Care Institutions in Baise City, Guangxi. The association between the infants of LGA risk and maternal interval age was analyzed, and the efficiency of maternal interval age in predicting LGA was analyzed by receiver operating characteristic (ROC) curve. Results During the follow-up of 2 032 pregnant women, the number of 67 cases had LGA, the incident rate was 3.3%. The delivery age, interval age and BMI of pregnant women in LGA group were higher than those in non-LGA group (all P < 0.05). In correlation analysis, after adjusting for confounding factors, there was no association between maternal interval age and birth weight (P=0.178), but the risk of LGA in pregnant women with maternal interval age ≥ 30 years was 29.214 times higher than that with maternal interval age < 10 years (P=0.018). The ROC curve analysis showed that the AUC of the overall prediction of maternal interval age and the delivery of female infants were 0.585 and 0.644, respectively, and the best cutoff point for the prediction of LGA by maternal interval age was 13 years old. Conclusion The longer the interval between delivery age and menarche age is, the higher the risk of LGA. The interval between delivery age and menarche age is a good predictor of LGA in female infant. |
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| Keywords: | Large for gestational age Menarche age Delivery age Birth cohort Pregnancy outcome |
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