| 上海市浦东新区腹泻病例中气单胞菌的流行和耐药特征研究 |
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| 引用本文： | 王闻卿,丁明,苏靖华,傅慧琴,赵冰,张勇琪,黄红,章红红,朱林英.上海市浦东新区腹泻病例中气单胞菌的流行和耐药特征研究[J].疾病监测,2016,31(3):225-228. |
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| 作者姓名： | 王闻卿 丁明 苏靖华 傅慧琴 赵冰 张勇琪 黄红 章红红 朱林英 |
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| 作者单位： | 1.上海市浦东新区疾病预防控制中心, 上海 200136 |
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| 基金项目： | Shanghai (No.PWRq2014-26) ，上海市浦东新区卫生系统优秀青年医学人才培养计划(No.PWRq2014-26) |
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| 摘 要： | 目的 了解上海市浦东新区腹泻病例中气单胞菌的流行及抗生素耐药特征。方法 2014年,在辖区内11家临床机构采集腹泻病例样本进行包括气单胞菌在内的腹泻多病原菌的检测,应用改良K-B法检测气单胞菌分离菌株对12种抗生素纸片的耐药性。结果 基于腹泻病例的实验室多病原诊断从1846份腹泻样本中共确认73例气单胞菌感染病例:单一型感染42例(57.6%),其中嗜水气单胞菌(嗜水)8例、维隆气单胞菌温和生物变种(温和)26例、豚鼠气单胞菌(豚鼠)8例;混合型感染31例(42.4%),总感染阳性率为4.0%。感染优势菌型为温和(P0.05),感染峰值为年度6-8月间(9.0%),病例的男女性别比差异无统计学意义,病例的年龄组以0~4岁和40~91岁人群居多。有65.8%(48/73)的气单胞菌对至少1种抗生素产生耐药性,以阿莫西林/克拉维酸(38.4%)和四环素(34.2%)的耐药率为最高,发现的3株多重耐药(MDR)株均为温和气单胞菌,其中1株对6种抗生素多重耐药(包括头孢噻肟、环丙沙星和左氧氟沙星)。结论 浦东新区和食源性感染性腹泻相关的气单胞菌病例存在较高的混合感染现象,发病有显著的季节特征,5岁以下幼儿和中老年人较为易感,温和气单胞菌是优势菌型,其对抗生素的多重耐药水平有升高趋势。
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| 关 键 词： | 气单胞菌 食源性感染性腹泻 混合感染 多重耐药 |
| 收稿时间： | 2015-11-26 |
Prevalence and antibiotic resistance of Aeromonasfrom diarrheal patients in Pudong New Area,Shanghai |
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| Affiliation: | 1.Pudong New District Center for Disease Control and Prevention, Shanghai, Shanghai 200136, China |
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| Abstract: | Objective To investigate the distribution and antibiotic resistance of Aeromonas isolated from the patients with acute diarrhea in Pudong New Area, Shanghai. Methods In 2014, Eleven hospitals were selected as sentinels in Pudong. The stool samples of diarrheal patients in 11 sentinel hospitals in Pudong were collected for the detection of diarrheal pathogens, including Aeromonas. The isolates were further detected for the susceptibility to 12 antibiotics with K-B method. Results A total of 73 Aeromonas infections were detected in 1846 samples (4.0%), including 42 single infections(57.6%) 8 A. hydrophila infections, 26 A. veronii bv. sobria infections, 8 A. caviae infections, and 31 co-infections with other pathogens(42.4%). A. veronii bv. sobria was the predominant pathogen (P0.05). The infection peak was during June-August (9.0%), the positive rates between males and females had no statistical significance, and the cases in age groups 0~4 years and 40-91 years accounted for 65.8%(48/73). Most Aeromonas strains were resistant to at least one antibiotic. The resistance rate to amoxicillin-clavulanic acid was highest(38.4%), followed by that to tetracycline(34.2%).Three MDR strains of A.veronii bv. sobria were detected, including 1 strain resistant to cefotaxime, ciprofloxacin, levofloxacin and other 3 antibiotics. Conclusion Aeromonas caused diarrhea had obviously seasonal/foodborne infection characteristics. High proportion of co-infections occurred. People aged 5 years and 40 years were susceptible. A.veronii bv.sobria was the predominant pathogen with increased MDR level. |
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| Keywords: | Aeromonas Foodborne infectious diarrhea Co-infection Multidrug resistance |
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