| 基质金属蛋白酶-9、基质金属蛋白酶-2在非负荷期种植体周围骨组织改建过程中的表达 |
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| 引用本文： | 刘丽,何福明,李乐乐,胡济安.基质金属蛋白酶-9、基质金属蛋白酶-2在非负荷期种植体周围骨组织改建过程中的表达[J].华西口腔医学杂志,2004,22(4):325-327. |
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| 作者姓名： | 刘丽 何福明 李乐乐 胡济安 |
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| 作者单位： | 浙江大学医学院附属口腔医院,修复科,浙江,杭州,310006;浙江大学医学院附属口腔医院,病理科,浙江,杭州,310006 |
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| 基金项目： | 浙江省自然科学基金资助项目 (397497) |
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| 摘 要： | 目的 探讨基质金属蛋白酶-9、2(MMP-9, MMP-2)在种植体与骨组织界面愈合过程中的作用。方法 在不同时间将种植体植入英国小猎兔犬的前牙及前磨牙区,取得种植不同时间段的标本,用免疫组织化学染色法观察不同时间段种植体周围骨组织中MMP-9、2表达的变化。结果 MMP-9主要表达在破骨细胞、巨噬细胞、衬细胞及成纤维细胞的细胞质中;MMP-2主要表达在成骨细胞、成纤维细胞的细胞质及部分破骨细胞中。结论 MMP-9、2 在种植体植入后周围损伤骨组织的吸收、愈合和骨重建中起重要作用。
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| 关 键 词： | 种植体 骨整合 基质金属蛋白酶 |
| 文章编号： | 1000-1182(2004)04-0325-03 |
| 收稿时间： | 2004-08-25 |
| 修稿时间： | 2004年1月2日 |
The Expression of MMP-9,MMP-2 in the Remodeling Bone Tissue around Implant during Unloaded Period |
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| LIU Li,HE Fu-ming,LI Le-le,HU Ji-an..The Expression of MMP-9,MMP-2 in the Remodeling Bone Tissue around Implant during Unloaded Period[J].West China Journal of Stomatology,2004,22(4):325-327. |
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| Authors: | LIU Li HE Fu-ming LI Le-le HU Ji-an |
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| Affiliation: | 1.Dept.ofProsthodontics,the Affiliated StomatologicHospital,College ofMedical Sci- ences,Zhejiang University;2.Dept.ofPathology,the Affiliated StomatologicalHospital,College ofMedical Sciences,Zhejiang University,Hangzhou310006,China |
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| Abstract: | OBJECTIVE: To discuss the function of MMP-9, MMP-2 in the remodeling bone tissue around implant during unloaded period. METHODS: At the anterior of the maxilla and mandibular of the Beagle dog, implants were placed at different periods, so the implant specimens of different periods were obtained after dogs were killed. The implant specimens were removed, fixed in 4% paraformaldehyde for 24 hours at 4 degrees C, decalcified with 10% EDTA at pH 7.2, embedded in paraffin wax and sectioned. The observation of the expression changes of the MMP-2, MMP-9 in the milien bone tissue of the implant at different periods were taken by immunohistochemical staining. RESULTS: Matrix metalloprotainase (MMP-9) was mostly expressed at the peripheral cytoplasmic of osteoclast, macrophage, lining cell and fibroblast. MMP-2 was mostly expressed at the peripheral cytoplasmic of osteoblast, fibroblast, some osteoclast also expressed this enzyme. CONCLUSION: MMP-2 and MMP -9 have an important function at the injured bone absorption, healing and bone remodeling after dental implant placement. |
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| Keywords: | implants osseointegretion matrix metalloprotainase |
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