| 2014~2019年郑州大学第一附属医院血培养分离病原菌临床分布及耐药性分析 |
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| 引用本文： | 徐慧,徐岷,刘彩林,李晓改,王红梅,叶亚菲,曾利.2014~2019年郑州大学第一附属医院血培养分离病原菌临床分布及耐药性分析[J].现代检验医学杂志,2021,0(1):136-140. |
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| 作者姓名： | 徐慧 徐岷 刘彩林 李晓改 王红梅 叶亚菲 曾利 |
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| 作者单位： | （郑州大学第一附属医院检验科，郑州 450052） |
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| 摘 要： | 目的 了解郑州大学第一附属医院血培养病原菌的构成及耐药性。方法 回顾性分析郑州大学第一附属医院 2014年 1月 ~2019年 12月间临床血培养分离的 13 456株细菌药敏结果，按照 CLSI2019年标准，使用 WHONET 5.6软件进行数据分析。结果 血培养分离前 5位的细菌分别为大肠埃希菌 3 121株（23.2%）、凝固酶阴性葡萄球菌 2 822株（21.0%）、肺炎克雷伯菌 2 038株（15.1%）、金黄色葡萄球菌 844株（6.3%）和屎肠球菌 727株（5.4%）。大肠埃希菌对亚胺培南、厄他培南的耐药率分别为 3.7%和 4.2%。肺炎克雷伯菌对亚胺培南、厄他培南的耐药率分别为 43.5%和 47.6%。鲍曼不动杆菌对大多数测试抗生素耐药性高，而铜绿假单胞菌对大多数抗生素保持较高的敏感性。耐甲氧西林金黄色葡萄球菌（ MRSA）和耐甲氧西林凝固酶阴性葡萄球菌（ MRCNS）的检出率分别为 42.1%和 84.2%，未发现万古霉素耐药的金黄色葡萄球菌。结论 郑州大学第一附属医院血培养分离细菌耐药情况较为严重，临床应合理应用抗生素，主动开展细菌耐药性监测，遏制细菌耐药性的上升。
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| 关 键 词： | 血培养 病原菌 耐药性 |
Clinical Distribution and Antibiotic Resistance of the Blood Cultureisolates from the First Affiliated Hospital of Zhengzhou University,2014~2019 |
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| XU Hui,XU Min,LIU Cai-lin,LI Xiao-gai,WANG Hong-mei,YE Ya-fei,ZENG Li.Clinical Distribution and Antibiotic Resistance of the Blood Cultureisolates from the First Affiliated Hospital of Zhengzhou University,2014~2019[J].Journal of Modern Laboratory Medicine,2021,0(1):136-140. |
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| Authors: | XU Hui XU Min LIU Cai-lin LI Xiao-gai WANG Hong-mei YE Ya-fei ZENG Li |
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| Affiliation: | （Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China） |
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| Abstract: | Objective To investigate the distribution and antibiotic resistance of clinical isolates from blood culture in the First Affiliated Hospital of Zhengzhou University.Methods A total of 13456 clinical strains collected from blood cultures in the First Affiliated Hospital of Zhengzhou University from Jun 2014 to Dec 2019 were analyzed retrospectively.The data were analyzed by WHONET 5.6 software according to the Clinical and Laboratory Standards Institute(CLSI)2019 breakpoints.Results The top five populations of the bacteria isolates were E.coli(23.2%),coagulase negative Staphylococci(21.0%),K.pneumoniae(15.1%),S.aureus(6.3%)and E.faecium(5.4%),respectively.The resistance rates of E.coli isolates to imipenem and meropenem were 3.7%and 4.2%,respectively.However,the resistance rates of K.pneumoniae isolates to imipenem and meropenem were 43.5%and 47.6%,respectively.Most of the tested antimicrobial agents revealed poor activity against A.baumannii isolates but good activity against P.aeruginosa isolates.The prevalence of methicillin resistant S.aureus(MRSA)and methicillin resistant coagulase negative Staphylococcus(MRCNS)were 42.1%and 84.2%,respectively.No vancomycin resistant S.aureus isolates were found.Conclusion The antimicrobial resistance of clinical isolates of blood cultures from the First Affiliated Hospital of Zhengzhou University was severe.Promoting the rational use of antimicrobial agents and conducting bacterial resistance surveillance actively should be strengthento prevent the increase of the bacteria drug resistance. |
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| Keywords: | blood culture pathogen drug resistance |
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