Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines |
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| Authors: | Defu Zeng Michael Dick Lirong Cheng Masahiko Amano Sussan Dejbakhsh-Jones Philip Huie Richard Sibley and Samuel Strober |
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| Affiliation: | From the Division of Immunology and Rheumatology, *Department of Medicine, and ‡Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5111 |
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| Abstract: | T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4+, CD8+, or CD4−CD8− T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti–double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4−CD8− T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-γ and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-γ or IL-10. |
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