Susceptibility to human cancer: From the perspective of a pathologist |
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| Authors: | Haruhiko Sugimura |
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| Affiliation: | Department of Tumor Pathology, Hamamatsu University School of Medicine, Higashi‐ku, Hamamatsu, Japan |
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| Abstract: | ![]()
The etiologies of human cancer can only be discerned when the genetic clustering of cancer occurs within a family or when cancer occurs endemically in a particular environment. The possible approaches to solving the nature/nurture problem, especially for human carcinogenesis, posit a fascinating challenge for pathologists. This perspective review presents some examples of how clues to human cancer etiologies and/or susceptibilities reside in the realm of pathology practice. These examples using various omics techniques including adductomics, which I would like to highlight in this article, show that the currently available concepts and methods in human pathology can open a path toward the brave new world of a post‐genomic era of medicine for young pathologists, whether their original intention was toward the pursuit of diagnostic or investigative knowledge. |
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| Keywords: | adductome adductomics cancer susceptibility exposome gene‐environmental interaction genetic polymorphism molecular epidemiology |
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