| 冠状动脉慢血流与外周血淋巴细胞和单核细胞比值之间的关联性分析 |
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| 引用本文： | 史静怡,丁邵祥,赵志林,王 炯.冠状动脉慢血流与外周血淋巴细胞和单核细胞比值之间的关联性分析[J].现代检验医学杂志,2020,0(1):139-142. |
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| 作者姓名： | 史静怡 丁邵祥 赵志林 王 炯 |
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| 作者单位： | (1.西安市第三医院心内科,西安 710021; 2.咸阳市第一人民医院心血管内一科,陕西咸阳 712000;
3.凤翔县中医医院检验科, 陕西宝鸡 721400) |
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| 摘 要： | 目的 探究淋巴细胞和单核细胞比值(lymphocyte-to-monocyte ratio, LMR)与冠状动脉慢血流(slow coronary flow, SCF)现象之间的关联性。方法 回顾性收集98例2016年9月～2017年11月在凤翔县中医医院因可疑有冠状动脉疾病,行冠状动脉造影检查的患者为研究对象。采用血液分析仪进行全血细胞计数。采用数字血管造影系统,基于心肌梗死后的血栓溶栓(thrombolysis in myocardial infarction, TIMI)计帧法检测冠状动脉血流量。根据冠状动脉造影结果将研究对象分为两组,包括45例SCF患者组和53例正常冠状动脉血流健康(normal coronary flow, NCF)对照组。采用Logistic回归分析LMR与SCF发生之间的关联性。结果 相比NCF患者,SCF患者组的高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)水平、嗜中性粒细胞、单核细胞计数,嗜中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio, NLR),C-反应蛋白(C-reactive protein, CRP)和心肌梗死后的血栓溶栓(thrombolysis in myocardial infarction, TIMI)帧数较高,但淋巴细胞计数和LMR较低,差异均有统计学意义(t=1.630～7.834, 均P<0.05)。LMR与左前降支(left anterior descending, LAD)动脉,左回旋支(left circumflex, LCX)侧动脉和右冠状(right coronary artery, RCA)动脉的TIMI帧数呈现负向关联性(r=-1.31,-1.05和-0.76,均P<0.001)。LMR单变量(OR=0.76, 95%CI=0.57～0.93,P=0.003)和多变量(OR=0.32, 95%CI=0.14～0.91,P=0.011)。logistic回归分析均发现LMR的升高与SCF的发生风险呈现负向关联性。结论 LMR与SCF的发生风险呈现负向关联性,可以作为SCF发生的一种预测性标志物。
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| 关 键 词： | 冠状动脉慢血流 淋巴细胞和单核细胞比值 炎性标志物 冠状动脉造影 关联性分析 |
Association of Slow Coronary Flow with Peripheral
Blood Lymphocyte-to-Monocyte Ratio |
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| SHI Jing-yi,DING Shao-xiang,ZHAO Zhi-lin,WANG Jiong.Association of Slow Coronary Flow with Peripheral
Blood Lymphocyte-to-Monocyte Ratio[J].Journal of Modern Laboratory Medicine,2020,0(1):139-142. |
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| Authors: | SHI Jing-yi DING Shao-xiang ZHAO Zhi-lin WANG Jiong |
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| Affiliation: | (1. Department of Cardiology,the Third Hospital of Xi' an, Xi' an 710021,China;
2. Department of Cardiovascular Medicine, the First People's Hospital of Xianyang City,Shaanxi Xianyang 712000,China;
3.Department of Clinical Laboratory,Fengxiang County Hospital of Traditional Chinese Medicine,Shaanxi Baoji 721400, China) |
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| Abstract: | Objective To investigate the association between lymphocyte-to-monocyte ratio(LMR)and slow coronary flow(SCF)phenomenon. Methods A total of 98 patients who had performed coronary angiography for suspected coronary artery disease, were retrospectively enrolled in the present study from June 2016 to November 2017 in Fengxiang Hospital. Whole blood counts were performed using a blood analyzer. Coronary blood flow was measured by a digital angiography system based on thrombolysis in myocardial infarction(TIMI)frame counting method after myocardial infarction. According to the results of coronary angiography, all subjects were divided into two groups, including 45 SCF patients and 53 normal coronary flow(NCF)controls. Logistic regression was used to analyze the association between LMR and SCF. Results Higher level of HDL, neutrophils and monocyte counts, neutrophil-to-lymphocyte ratio(NLR), C-reactive protein(CRP)and thrombolysis in myocardial infarction(TIMI)frame counts, and lower level of lymphocyte counts were found among SCF group than NCF group,the difference was statistically significant(t=1.630～7.834, all P<0.05). LMR was negatively associated with frame counts of left anterior descending(LAD), left circumflex artery(LCX)and right coronary artery(RCA)(r= -1.31,-1.05, -0.76, all P<0.001). In addition, increased LMR was negatively associated with risk of SCF in both univariate(OR=0.76, 95%CI=0.57～0.93,P=0.003)and multiple(OR=0.32, 95%CI=0.14～0.91,P=0.011)logistic regression models. Conclusion LMR was negatively associated with risk of SCF, and LMR may play as a predictive biomarker of incident SCF. |
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