人3型副流感病毒疫苗研究进展 |
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引用本文: | 邱陈晨,李秀玲. 人3型副流感病毒疫苗研究进展[J]. 国际生物制品学杂志, 2022, 45(6): 343-348. DOI: 10.3760/cma.j.cn311962-20220222-00015 |
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作者姓名: | 邱陈晨 李秀玲 |
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作者单位: | 1上海生物制品研究所有限责任公司第四研究室,上海 200051;2上海生物制品研究所有限责任公司,上海 200051 |
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摘 要: | 人副流感病毒(human parainfluenza virus,HPIV)主要引起5岁以下儿童急性呼吸道感染,临床发病率仅次于呼吸道合胞病毒感染,其中超过一半病例由HPIV-3引起,给新生儿的生命健康带来极大威胁,而目前仍然没有批准上市的针对HPIV的有效治疗药物及疫苗。此文就HPIV-3的基本结构、流行病学、感染免疫,以及目前针对HPIV-3疫苗的研发进展做一综述。
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关 键 词: | 副流感病毒3型 人;疫苗;呼吸道感染 |
Research progress of human parainfluenza virus type 3 vaccine |
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Abstract: | Human parainfluenza virus type 3 (HPIV-3) mainly causes acute respiratory infection among kids under 5 years old and the incidence is merely lower than that of respiratory syncytial virus, among which over half are caused by HPIV-3. This is a serious threat to newborn lives. There is no approved vaccine or drug for HPIV up to now. This review systematically introduce the structure, epidemiology, infection, immunization, and current vaccine development progresses of HPIV-3. |
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Keywords: | Parainfluenza virus 3 human Vaccines Respiratory tract infections |
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