Mycobacterium avium subsp. paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle |
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| Authors: | Buza Joram J Mori Yasuyuki Bari Abusaleh M Hikono Hirokazu Aodon-geril Hirayama Sachiyo Shu Yujing Momotani Eiichi |
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| Affiliation: | Paratuberculosis and Inflammatory Bowel Disease Research Team, National Institute of Animal Health, 3-1-5 Kan-nondai, Tsukuba 305-0856, Japan. |
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| Abstract: | Blood from cattle with subclinical Mycobacterium avium subsp. paratuberculosis infection was stimulated with M. avium subsp. paratuberculosis antigens, and expression of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), RANTES, monocyte chemoattractant protein 1 (MCP-1), and IL-8 was measured. Expression of TNF-alpha, RANTES, and MCP-1 was lower in infected than in uninfected cattle. The reduced response may weaken protective immunity and perpetuate infection. |
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