| 聚焦超声热消融及开放血脑屏障治疗脑部疾病的研究进展 |
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| 引用本文： | 罗凯旋,林爱金,陈茉弦,张留影,易沙沙,敖丽娟.聚焦超声热消融及开放血脑屏障治疗脑部疾病的研究进展[J].临床超声医学杂志,2020,22(6):448-451. |
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| 作者姓名： | 罗凯旋 林爱金 陈茉弦 张留影 易沙沙 敖丽娟 |
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| 作者单位： | 650000 昆明市,昆明医科大学康复学院 |
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| 基金项目： | 云南省教育厅科研项目;国家自然科学基金 |
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| 摘 要： | 聚焦超声是一种新兴的非侵入式治疗方法。在特定参数下,聚焦超声可经颅骨对颅内组织进行热消融,也可联合微泡可逆地开放血脑屏障,提高药物疗效以治疗脑部疾病。目前,聚焦超声在治疗原发性震颤、帕金森病、精神病、脑肿瘤、神经病理性疼痛等脑部疾病方面取得了一定研究进展。本文就聚焦超声热消融及开放血脑屏障治疗脑部疾病的研究进展进行综述。
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| 关 键 词： | 聚焦超声 热消融 血脑屏障 药物递送 脑部疾病 |
Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases |
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| LUO Kaixuan,LIN Aijin,CHEN Moxuan,ZHANG Liuying,YI Shasha,AO Lijuan.Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases[J].Journal of Ultrasound in Clinical Medicine,2020,22(6):448-451. |
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| Authors: | LUO Kaixuan LIN Aijin CHEN Moxuan ZHANG Liuying YI Shasha AO Lijuan |
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| Affiliation: | (the School of Rehabilitation,Kunming Medical University,Kunming 650000,China) |
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| Abstract: | As a novel non-invasive treatment method,focused ultrasound(FUS)can be used to treat brain diseases via thermal ablation of intracranial tissues under specific parameters transcranially.Combined with microbubbles,it can also be used to enhance the efficiency of drug delivery by opening the blood-brain barrier reversibly.Nowadays,Progress has been made in treatment of brain diseases such as essential tremor,Parkinson’s disease,psychosis,brain tumor and neuropathic pain with FUS.This article reviews the research progress of FUS thermal ablation and FUS-induced opening of the blood-brain barrier in the treatment of cerebral diseases. |
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| Keywords: | Focused ultrasound Thermal ablation Blood-brain barrier Drug delivery Brain diseases |
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