Production of macrophage inflammatory protein 3alpha (MIP-3alpha) (CCL20) and MIP-3beta (CCL19) by human peripheral blood neutrophils in response to microbial pathogens |
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| Authors: | Akahoshi Tohru Sasahara Takeshi Namai Rie Matsui Toshimichi Watabe Hiroyuki Kitasato Hidero Inoue Matsuhisa Kondo Hirobumi |
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| Affiliation: | Department of Laboratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan. akahoshi@med.kitasato-u.ac.jp |
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| Abstract: | Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets. |
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