| 硼替佐米治疗多发性骨髓瘤的疗效 |
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| 引用本文： | 贾垂明,王燕,梁欢,刘爱春. 硼替佐米治疗多发性骨髓瘤的疗效[J]. 现代肿瘤医学, 2014, 0(10): 2439-2441. DOI: 10.3969/j.issn.1672-4992.2014.10.56 |
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| 作者姓名： | 贾垂明 王燕 梁欢 刘爱春 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院，黑龙江 哈尔滨 150081 |
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| 摘 要： | 目的:观察硼替佐米治疗多发性骨髓瘤的疗效及不良反应。方法:多发性骨髓瘤患者26例，均给予以硼替佐米为基础的联合方案治疗，患者分别接受2-6个周期治疗。结果:26例患者在接受2个疗程硼替佐米治疗后，其中2例患者完全缓解，7例患者达非常好的部分缓解，16例患者部分缓解，1例患者出现疾病进展。不良反应主要有周围神经病变、血液学毒性、消化道症状以及感染等，经对症支持大部分可以缓解。结论:硼替佐米对于多发性骨髓瘤起效快，有一定程度不良反应，但大部分可逆转。
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| 关 键 词： | 多发性骨髓瘤 疗效 不良反应 硼替佐米 |
Curative effect of bortezomib in treatment of multiple myeloma |
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| Jia Chuiming,Wang Yan,Liang Huan,Liu Aichun. Curative effect of bortezomib in treatment of multiple myeloma[J]. Journal of Modern Oncology, 2014, 0(10): 2439-2441. DOI: 10.3969/j.issn.1672-4992.2014.10.56 |
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| Authors: | Jia Chuiming Wang Yan Liang Huan Liu Aichun |
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| Affiliation: | The Affiliated Tumor Hospital of Harbin Medical University,Heilongjiang Harbin 150081,China. |
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| Abstract: | Objective：To observe the therapeutic effects and adverse effects of bortezomib in treatment of multiple myeloma. Methods：26 patients with multiple myeloma treated in our hospital,they all received bortezomib based regi-mens respectively from 2 -6 cycles. Results：2 patients achieved complete response,7 patients achieved very good complete response,16 patients achieved partial response,1 patient with progressive disease. Adverse events included peripheral neuropathy,hematologic toxicities,gastrointestinal and infection. . They were reversed with appropriate sup-portive care. Conclusion：Bortezomib is effective and works fast in treatment of multiple myeloma,having a certain de-gree adverse reaction,but most can be reversed. |
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| Keywords: | multiple myeloma curative effect adverse effects bortezomib |
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