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Successful treatment with placenta‐derived decidual stromal cells in a pediatric patient with life‐threatening acute gastrointestinal graft‐versus‐host disease |
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| Authors: | Britt Gustafsson Per Frisk Attilla Szakos Behnam Sadeghi Olle Ringdén Britt‐Marie Frost |
| Affiliation: | 1. Department of Clinical Intervention and Technology, CLINTEC, Karolinska Institutet, Stockholm, Sweden;2. Department of Women's and Children's Health, Pediatric Oncology, Children's University Hospital, Uppsala, Sweden;3. Department of Women's and Children's Health, Uppsala University Hospital, Uppsala, Sweden;4. Department of Pathology and Cytologi, Karolinska University Hospital, Stockholm, Sweden;5. Department of Laboratory Medicine, Division of Therapeutic Immunology, Karolinska Institutet, Stockholm, Sweden |
| Abstract: | Severe aGvHD is a life‐threatening complication after allogeneic HSCT. The GI tract is considered to play a key role in aGvHD, where the disease process can start and is one of the major target organs. Here, we present a case of a one‐year‐old child with a life‐threatening GI‐aGvHD stage IV, post‐HSCT, resistant to steroids and MMF for 4 weeks. He was successfully treated with placenta‐derived DSC. |
| Keywords: | acute graft‐versus‐host disease decidual stromal cells pediatric allogeneic hematopoietic stem cell transplantation steroid‐refractory gastrointestinal bleedings |