Sputum itraconazole concentrations in cystic fibrosis patients |
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| Authors: | Sermet-Gaudelus I Lesne-Hulin A Lenoir G Singlas E Berche P Hennequin C |
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| Affiliation: | Service de Pédiatrie Générale, H?pital Necker-Enfants Malades, 75015 Paris, France. sermut-gaudelus@necker.fr |
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| Abstract: | Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients with allergic bronchopulmonary aspergillosis. There was a high interindividual variability in sputum itraconazole concentration and sputum/serum drug concentration ratio. Three children had sputum drug concentrations before oral administration that were lower than the itraconazole MIC at which 90% of Aspergillus fumigatus strains were inhibited, although their serum drug concentrations were within the therapeutic range. |
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