| 法舒地尔治疗结缔组织病相关肺间质病变疗效观察 |
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| 引用本文： | 何宏军,寇静鑫,王玲,马莹莹. 法舒地尔治疗结缔组织病相关肺间质病变疗效观察[J]. 蚌埠医学院学报, 2016, 41(6): 769-771. DOI: 10.13898/j.cnki.issn.1000-2200.2016.06.020 |
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| 作者姓名： | 何宏军 寇静鑫 王玲 马莹莹 |
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| 作者单位： | 江苏省泰兴市人民医院 风湿免疫科, 225400 |
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| 摘 要： | 目的:观察法舒地尔对结缔组织病相关肺间质病变的治疗效果。方法:将62例结缔组织病肺间质病变患者随机分为对照组32例和治疗组30例。对照组行常规治疗，治疗组在常规治疗的基础上加用法舒地尔30 mg加入250 mL 0.9%氯化钠注射液静脉滴注，疗程14 d。对治疗前后行6 min步行实验、超声心动图测肺动脉压力、高分辨率胸部CT、血气分析及红细胞沉降率、C反应蛋白等进行对比。结果:用药后治疗组6 min步行距离增加，肺动脉压降低，高分辨率胸部CT评分降低，疾病活动度减轻，与用药前及对照组用药后差异均有统计学意义（P < 0.01）。结论:法舒地尔治疗结缔组织病相关肺间质病变有效。
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| 关 键 词： | 结缔组织疾病 肺间质病变 激酶抑制剂 法舒地尔 弥漫性 |
| 收稿时间： | 2014-07-31 |
Clinical effect of fasudil in the treatment of interstitial lung disease associated with connective tissue disease |
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| HE Hong-jun,KOU Jing-xin,WANG Ling,MA Ying-ying. Clinical effect of fasudil in the treatment of interstitial lung disease associated with connective tissue disease[J]. Journal of Bengbu Medical College, 2016, 41(6): 769-771. DOI: 10.13898/j.cnki.issn.1000-2200.2016.06.020 |
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| Authors: | HE Hong-jun KOU Jing-xin WANG Ling MA Ying-ying |
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| Affiliation: | Department of Rheumatology, The People's Hospital of Taixing, Taixing Jiangsu 225400, China |
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| Abstract: | Objective: To observe the clinical effects of fasudil in the treatment of interstitial lung disease associated with connective tissue disease.Methods: Sixty-two patients with interstitial lung disease associated with connective tissue disease were randomly divided into the control group(32 cases) and treatment group(30 cases).The control group were treated with conventional measures,and the treatment group were additionally treated with 30 mg fasudil based on the control group for 14 days.The 6-min walk test,pulmonary arterial pressure measured by echocardiography,high chest resolution CT and blood gas analysis and erythrocyte sedimentation rate and C reactive protein before and after treatment were compared.Results: After treatment,the 6-min walk distance increased,pulmonary artery pressure dropped,high resolution chest CT score decreased and activity reduced.The differences of whose between treatment groupbeforeand after treatment,and control group were statistically significant(P < 0.01).Conclusions: The treatment of interstitial lung disease associated with connective tissue disease with fasudilis effective. |
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| Keywords: | connective tissue disease interstitial lung disease kinase inhibitor fasudil diffusion |
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