| 大鼠口服东莨菪素后的组织分布和排泄特征研究(英文) |
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| 引用本文： | 夏玉凤,戴岳,梁惠贞. 大鼠口服东莨菪素后的组织分布和排泄特征研究(英文)[J]. 中国药学, 2012, 21(2): 149-155. DOI: 10.5246/jcps.2012.02.019 |
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| 作者姓名： | 夏玉凤 戴岳 梁惠贞 |
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| 作者单位： | 中国药科大学天然药物活性组分与药效国家重点实验室;中国药科大学中药药理教研室 |
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| 基金项目： | The Fundamental Research Funds for the Central Universities(Grant No.JKZ2011016);the Priority Academic Program Development of Jiangsu Higher Education Institutions |
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| 摘 要： | 研究东莨菪素在大鼠体内的组织分布和排泄特征,SD大鼠灌胃东莨菪素(50mg/kg),分别于给药后5,15,30,60,120,240分钟取大鼠心、肝、脾、肺、肾、肌肉、脂肪、脑、睾丸、子宫、胃、小肠等组织器官测定其原形药物浓度。结果表明,东莨菪素广泛分布于各组织器官且于给药后15分钟浓度即达峰值,其中肝、肾、胃和小肠含量较高。此外,东莨菪素在胆汁、尿液、粪便的排泄研究显示,胆汁、尿液、粪便的累积排泄量分别为0.032%,3.752%和0.784%。表明东莨菪素在大鼠体内主要以代谢物的形式消除。
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| 关 键 词： | 东莨菪素 组织分布 排泄 |
Studies on tissue distribution and excretion of scopoletin after oral administration in rats |
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| Yu-Feng Xia,Yue Dai,Hui-Zhen Liang. Studies on tissue distribution and excretion of scopoletin after oral administration in rats[J]. Journal of Chinese Pharmaceutical Sciences, 2012, 21(2): 149-155. DOI: 10.5246/jcps.2012.02.019 |
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| Authors: | Yu-Feng Xia Yue Dai Hui-Zhen Liang |
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| Affiliation: | 1.State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China 2.Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | The present study aimed at studying the characteristics of tissue distribution and excretion of scopoletin,a coumarin compound,in Sprague-Dawley rats.Scopoletin was orally administered at a dose of 50 mg/kg,and the concentrations in heart,liver,spleen,lung,kidney,muscle,fat,brain,testis,uterus,stomach and small intestine were determined at 5,15,30,60,120,240 min post-dose,respectively.It was shown that scopoletin was widely distributed into various tissues and reached the maximal concentrations in most tissues at 15 min post-dose,and the levels in liver,kidney,stomach and small intestine were relatively higher.Furthermore,the excretions of scopoletin in bile,urine and feces were only 0.032%,3.752% and 0.784%,respectively,suggesting that scopoletin was mainly eliminated by metabolism rather than excretion as parent drug. |
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| Keywords: | Scopoletin Tissue distribution Excretion |
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