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More ZAP for chronic lymphocytic leukemia (CLL) |
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| Authors: | Wiestner Adrian |
| Affiliation: | National Heart, Lung and Blood Institute. |
| Abstract: | Antigen stimulation of the leukemic clone is increasingly implicated in the pathogenesis of CLL. Chen and colleagues provide evidence that expression of ZAP-70 in CLL B cells renders IgM signaling more effective and thereby could contribute to the more rapidly progressive clinical course of ZAP-70-positive CLL. |
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