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| 转录因子SOX2在宫颈上皮内瘤样病变及宫颈癌中的表达及临床意义 | |
| 引用本文： | 蔡春芳,谭国胜,俞奇,栾峰,余雷,王莹.转录因子SOX2在宫颈上皮内瘤样病变及宫颈癌中的表达及临床意义[J].南方医科大学学报,2013,33(1):128-130. |
| 作者姓名： | 蔡春芳 谭国胜 俞奇 栾峰 余雷 王莹 |
| 作者单位： | 1. 中山市博爱医院妇产科,广东中山,528400 2. 中山大学附属第一医院介入放射科,广东广州,510080 3. 广西自治区人民医院肿瘤科,广西南宁,530021 |
| 基金项目： | 广东省自然科学基金，广东省医学科研基金 |
| 摘 要： | 目的研究SOX2 在宫颈上皮内瘤样病变（CIN）及宫颈癌组织中的表达，探讨其与CIN 疾病及宫颈癌临床特征的相关 性。方法应用免疫组化SP法，检测10例正常宫颈、36例不同级别CIN（I级10例，Ⅱ级12 例，Ⅲ级14例）、40例宫颈癌组织（I期 21例，Ⅱ期19例）中SOX2蛋白的表达情况，分析比较其表达与临床特征的关系。结果（1）SOX2蛋白在正常宫颈组织中表达率 均为0%，在36例CIN组织中阳性表达率为41.6%（15/36），其中CINⅠ级10.0%，CINⅡ级41.7%，CINⅢ级64.3%；而40例宫颈癌 组织SOX2蛋白阳性表达率为82.5%（33/40），其中宫颈癌Ⅰ期78.2%，Ⅱ期88.2%。随着宫颈病变进展，SOX2的阳性表达率呈 递增趋势。（2）SOX2蛋白表达与宫颈癌病理组织分级及淋巴结转移相关（P<0.05），与宫颈癌患者的年龄、临床分期无明显相关 关系（P>0.05）。结论SOX2蛋白表达水平与CIN疾病及宫颈癌恶性度及淋巴结转移呈正相关，检测SOX2对了解CIN及宫颈 癌生物学行为和评估预后具有一定的临床价值。 |
| 关 键 词： | SOX2 宫颈上皮内瘤样病变 宫颈癌 |
Expression of SOX2 in cervical intraepithelial neoplasia and cervical cancer and its clinical significance |
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| CAI Chunfang , TAN Guosheng , YU Qi , LUAN Feng , YU Lei , WANG Ying.Expression of SOX2 in cervical intraepithelial neoplasia and cervical cancer and its clinical significance[J].Journal of Southern Medical University,2013,33(1):128-130. | |
| Authors: | CAI Chunfang TAN Guosheng YU Qi LUAN Feng YU Lei WANG Ying |
| Affiliation: | 1Department of Gynecology and Obstetrics,Zhongshan Boai Hospital,Zhongshan 528400,China;2Department of Interventional Radiology,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;3Department of Oncology,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China |
| Abstract: | Objective To investigate the expression of SOX2 in cervical intraepithelial neoplasia (CIN) and cervical cancer and explore its association with the clinical features. Methods SOX2 expressions were examined using immunohistochemical method in 10 normal cervical tissue specimens, 36 cervical intraepithelial neoplasia specimens (including 10 cases of grade I, 12 of grade II, and 14 grade III) and 40 cervical cancer specimens (including 21 cases of stage I and 19 of stage II). The correlation between the immunohistochemical results and the clinical features of the patients was analyzed. Results SOX2 expression was negative in normal cervical tissues, and was positive in 41.6% of CIN specimens (10.0% in CIN I, 41.7% in CIN II, and 64.3% in CIN III) in 82.5% of cervical cancer specimens (78.2% in stage I and 88.2% in stage II). The patients with cervical cancer had a significantly higher positivity rate of SOX2 than normal control group (P<0.05). The positivity rate of SOX2 increased with the evolution of cervical disease. SOX2 protein expression was significantly correlated with the histological grade and lymph node metastasis (P<0.05), but not with the age or clinical stage of the patients (P>0.05). Conclusion SOX2 expression may serve as a useful indicator for evaluating metastasis and malignancy of cervical cancer. |
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