| 低剂量电离辐射诱导小鼠脑c－fos原癌基因的表达 |
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| 引用本文： | 万虹,龚守良,刘树铮.低剂量电离辐射诱导小鼠脑c－fos原癌基因的表达[J].中华放射医学与防护杂志,1996(1). |
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| 作者姓名： | 万虹 龚守良 刘树铮 |
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| 作者单位： | 白求恩医科大学卫生部放射生物重点实验室 |
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| 摘 要： | 应用原位杂交方法观察７５ｍＧｙ全身照射后不同时间小鼠脑神经元ｃ－ｆｏｓ原癌基因ｍＲＮＡ水平的变化。结果发现，７５ｍＧｙ全身照射可诱导小鼠脑内广泛神经元ｃ－ｆｏｓ的表达，大脑皮质和下丘脑尤为明显。照射后１５分钟ｃ－ｆｏｓｍＲＮＡ即出现，１小时最为明显，２小时后逐渐减少，８小时完全消失。提示低剂量辐射可增加神经元的活性。
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| 关 键 词： | 低剂量照射，原癌基因，原位杂交 |
Expression of c-fos protooncogene in mouse brain following low dose irradiation |
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| Wan Hong,Gong Shouliang and Liu Shuzheng.Expression of c-fos protooncogene in mouse brain following low dose irradiation[J].Chinese Journal of Radiological Medicine and Protection,1996(1). |
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| Authors: | Wan Hong Gong Shouliang and Liu Shuzheng |
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| Abstract: | in situ hybridization was used to examine the expression of c-fos mRNA in mouse brain following whole body irradiation(WBI) with 75 mGy X-rays. The results showed that WBI with 75 mGy could stimulate the expression of c-fos in extensive areas of neurons in the mouse brain, especially in the cerebral cortex and hypothalamus.The c-fos mRNA appeared 15 min after irradiation, reached its peak within 1 h and began to fade at 2 h with its total disappearance 8 h after irradiation. These findings indicate that low dose radiation can enhance the activity of the neurons in certain areas of the brain. |
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| Keywords: | Low dose radiation protooncogene in situ hybridization |
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