| QKI蛋白在恶性肿瘤中的研究进展及临床意义 |
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| 引用本文： | 张婷,侯光营,王鑫.QKI蛋白在恶性肿瘤中的研究进展及临床意义[J].实用肿瘤学杂志,2018,32(3):263-266. |
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| 作者姓名： | 张婷 侯光营 王鑫 |
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| 作者单位： | 1.哈尔滨医科大学病理教研室(哈尔滨 150081);2.河北省沧州市中西医结合医院肿瘤内科;3.哈尔滨医科大学附属第二医院耳鼻喉头颈外科 |
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| 基金项目： | 国家自然科学基金青年基金(编号:81400443) |
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| 摘 要： | QKI蛋白是STAR蛋白家族的一员,主要包含QKI-5、QKI-6和QKI-7三个亚型,早期研究发现QKI蛋白与神经髓鞘和胚胎发育密切相关。随着分子生物学的发展和基因技术的广泛应用,QKI蛋白在恶性肿瘤中的作用日益受到人们的重视。QKI蛋白在肺癌、胃癌、前列腺癌中的研究显示了其有抑制肿瘤侵袭能力的作用,并有可能成为一种恶性肿瘤诊断和治疗的新靶点。尽管QKI蛋白在恶性肿瘤中的广泛研究取得了重大进展,然而还存在许多疑点需要解答,有待于进一步的研究。
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| 关 键 词： | QKI蛋白 恶性肿瘤 抑制肿瘤 |
| 收稿时间： | 2017-06-22 |
Research progress and clinical significance of QKI protein in malignant tumor |
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| ZHANG Ting,HOU Guangying,WANG Xin,HE Yan.Research progress and clinical significance of QKI protein in malignant tumor[J].Journal of Practical Oncology,2018,32(3):263-266. |
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| Authors: | ZHANG Ting HOU Guangying WANG Xin HE Yan |
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| Affiliation: | 1.Department of Pathology,Harbin Medical University,Harbin 150081,China;2.Department of Oncology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine;3.Department of Otorhinolaryngology and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University |
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| Abstract: | QKI protein is a kind of STAR protein family and mainly contains three subtypes of QKI-5,QKI-6 and QKI-7.Early studies showed that QKI protein is closely related to the development of nerve myelin and embryo.With the development of molecular biology and the extensive application of gene technology,the effect of QKI protein on malignant tumors has received increasing attention.The studies of QKI protein from lung,gastric and prostate cancers have shown that it has the ability to inhibit tumor invasion,and may become a new target for the diagnosis and treatment of malignant tumors.Although significant progress has been made in the extensive research of QKI protein in malignant tumors,there are still many doubtful points that need to be answered.Thus,further research and exploration of QKI are needed in malignant tumor. |
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| Keywords: | QKI protein Malignant tumor Tumor suppression |
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