Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection |
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| Authors: | Cehovin Ana Cliff Jacqueline M Hill Philip C Brookes Roger H Dockrell Hazel M |
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| Affiliation: | Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom. a.cehovin@ucl.ac.uk |
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| Abstract: | To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture. |
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