| 垂体腺瘤术后外周血T淋巴细胞亚群及血清MMP-9水平的变化 |
| |
| 引用本文： | 李承科,何琴,唐辉,冯浩,付安辉.垂体腺瘤术后外周血T淋巴细胞亚群及血清MMP-9水平的变化[J].中国临床神经外科杂志,2018,0(2):87-89. |
| |
| 作者姓名： | 李承科 何琴 唐辉 冯浩 付安辉 |
| |
| 作者单位： | 作者单位:637000 四川，南充市中心医院神经外科（李承科、唐 辉、冯 浩、付安辉）；637000 四川南充，川北医学院第二临床学院儿科（何 琴） |
| |
| 摘 要： | 目的 探讨内镜下和显微镜下经鼻蝶入路切除垂体腺瘤术后病人外周血T淋巴细胞亚群及血清基质金属蛋白酶-9（MMP-9）水平的变化。方法 2014年6月至2017年3月收治符合标准的垂体腺瘤89例，根据治疗方法分为观察组（45例）和对照组（44例）。观察组采用内镜下经鼻蝶入路切除垂体腺瘤，对照组采用显微镜下经鼻蝶入路切除垂体腺瘤。结果 与对照组相比，观察组术中出血量明显减少（P<0.05），手术时间与住院时间明显缩短（P<0.05），术后并发症发生率明显降低（P<0.05）；术后3个月CD3+、CD4+、CD4+/CD8+水平均明显升高（P<0.05），血清MMP-9水平明显降低（P<0.05）。结论 与显微镜下手术相比，内镜下经鼻蝶入路切除垂体腺瘤可明显减轻手术创伤，改善外周血T淋巴细胞亚群及血清MMP-9水平，减少并发症发生。
|
| 关 键 词： | 垂体腺瘤 神经内镜 显微镜 经鼻蝶入路 手术 |
Effects of neuroendoscope-assisted surgery via single-nostril transsphenoidal approach for pituitary adenomas on the levels of peripheral blood T lymphocyte subsets and serum MMP-9 |
| |
| LI Chengke,HE Qin,TANG Hui,FENG Hao,FU An-hui..Effects of neuroendoscope-assisted surgery via single-nostril transsphenoidal approach for pituitary adenomas on the levels of peripheral blood T lymphocyte subsets and serum MMP-9[J].Chinese Journal of Clinical Neurosurgery,2018,0(2):87-89. |
| |
| Authors: | LI Chengke HE Qin TANG Hui FENG Hao FU An-hui |
| |
| Affiliation: | 1. Department of Neurosurgery, Nanchong Municipal Central Hospital, Nanchong 637000, China; 2. Department of Pediatrics, The Second Clinical School, North Sichuan Medical College, Nanchong 637000, China |
| |
| Abstract: | Objective To investigate the effects of neuroendoscope-assisted surgery via single-nostril transsphenoidal approach (SNTA) for pituitary adenomas on postoperative peripheral blood T lymphocyte subsets and levels of serum matrix metalloproteinase-9 (MMP-9). Methods Eighty-nine patients with pituitary adenomas treatment in Nanchong Municipal Central Hospital were randomly divided into two groups, i.e. observation group, in which 45 patients underwent neuroendoscope-assisted surgery via SNTA and 44 patients underwent microscope-assisted surgery via SNTA. The operative duration, hospital stay, postoperative complications and the levels of peripheral blood T lymphocyte subsets and serum MMP-9 before and 3 months after the operation were compared between both the groups. Results The operative duration and hospital stay were significantly shorter and intraoperative blood loss volume was significantly less in the observation group than those in the control group (P<0.05). The rate of postoperative complications occurrence was significantly lower in the observation group than that in the control group (P<0.05). The levels of peripheral blood CD3+, CD4+ and CD4+/CD8+ were significantly higher and the level of serum MMP-9 was significantly lower in the observation group than those in the control group 3 months after the operation (P<0.05). Conclusion The neuroendoscope-assisted surgery via SNTA, which can significantly reduce the surgical trauma, improve the levels of peripheral blood T lymphocyte subsets and serum MMP-9, may be helpful to promoting the postoperative rehabilitation in the patients with pituitary adenomas. |
| |
| Keywords: | Pituitary adenomas Surgery Neuroendoscope Microscope Single-nostril transsphenoidal approach |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国临床神经外科杂志》浏览原始摘要信息 |
|
点击此处可从《中国临床神经外科杂志》下载全文 |
