| 促红细胞生成素治疗大鼠急性脊髓损伤的Meta分析 |
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| 引用本文： | 罗海涛,周洪龙,李江浩,吕世刚,程祖珏.促红细胞生成素治疗大鼠急性脊髓损伤的Meta分析[J].中国临床神经外科杂志,2018,0(7):471-475. |
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| 作者姓名： | 罗海涛 周洪龙 李江浩 吕世刚 程祖珏 |
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| 作者单位： | 作者单位:330006 南昌，南昌大学第二附属医院神经外科 |
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| 摘 要： | 目的 探讨促红细胞生成素（EPO）对急性脊髓损伤大鼠运动功能恢复的影响。方法 计算机检索PubMed、Embase、Cochrane及中国生物医学数据库、维普信息数据库、中国知网及万方数据库，检索时限为数据库建库至2018年2月。采用Stata12.0软件进行Meta分析。结果 共纳入16个随机对照研究，包含303只大鼠，其中EPO组152只，对照组151只。Meta分析结果表明，EPO治疗后1、2、3、4、8周，大鼠BBB评分明显高于对照组（P<0.05），6周时差异无统计学意义（P>0.05）。结论 EPO能促进脊髓损伤大鼠的运动功能恢复。
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| 关 键 词： | 脊髓损伤 促红细胞生成素 大鼠 BBB评分 Meta分析 |
Treatment of acute spinal cord injury with erythropoietin in rats: a meta-analysis |
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| LUO Hai-tao,ZHOU hong-long,LI jiang-hao,LV shi-gang,CHENG zu-jue..Treatment of acute spinal cord injury with erythropoietin in rats: a meta-analysis[J].Chinese Journal of Clinical Neurosurgery,2018,0(7):471-475. |
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| Authors: | LUO Hai-tao ZHOU hong-long LI jiang-hao LV shi-gang CHENG zu-jue |
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| Affiliation: | Department of Neurosurgery, Second Affiliated Hospital, Nanchang University, Nanchang 330006, China |
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| Abstract: | Objective To explore the effects of erythropoietin (EPO) on the motor function in rats with acute spinal cord injury (aSCI). Methods The databases including PubMed, Embase, Cochranel Library, CBMdisc, VIP and WangFang were searched for the original articles about the study of the effects of EPO on the motor function in rats with aSCI. The quality of the articles was appraised according to the standard and data were extracted independently by 2 investigators. The methodology of involved trials was strictly assessed. Stata 12.0 software was used for data analysis. Results Sixteen articles of the randomized controlled trials involving 303 rats, of whom, 152 were in EPO group and 151 in the control group, were collected. The results of mta-analysis showed that the Bass Beattie Bresnahan (BBB) scale scores were significantly higher in EPO group 1, 2, 3, 4 and 8 weeks after aSCI than those in the control group WMD=2.577, 3.304, 4.796, 4.121, 3.537; 95%CI: (1.288, 3.865), (1.652, 4.957), (2.022, 7.571), (2.623, 5.618), (1.308, 5.765)] while there was no significant difference in BBB scale scores between both the groups 6 weeks after aSCI WMD=1.981; 95%CI: (-0.370, 4.332)]. Conclusions EPO can promote the recovery of motor function in rats with aSCI, but the effectiveness required being confirmed by the randomized controlled trials of larger sample. |
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| Keywords: | Spinal cord injury Erythropoietin Motor function Meta-analysis Rats |
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