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Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes. |
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| Authors: | R. Carnuccio M. Di Rosa P. Persico |
| Abstract: | Rat peritoneal luecocytes incubated with hydrocortisone (10 micrograms/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of antiinflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis. |
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