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Novel function for the p38‐MK2 signaling pathway in circulating CD1c+ (BDCA‐1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL‐12 whilst suppressing IL‐10
Authors:Hester A. Franks  Qunwei Wang  Stephanie J. Lax  Mary K. Collins  David Escors  Poulam M. Patel  Andrew M. Jackson
Affiliation:1. Host:Tumour Interactions Group, Academic Unit of Clinical Oncology University of Nottingham, United Kingdom;2. MRC Centre for Medical Molecular Virology, University College London, United Kingdom;3. Immunomodulation group, Navarrabiomed‐Fundacion Miguel Servet National Health Service of Navarre, Pamplona, Navarra, Spain
Abstract:
Keywords:dendritic cell  signaling  IL‐12  Th1  p38
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