| 视黄醇结合蛋白4和内脂素与非酒精性脂肪肝的相关性研究 |
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| 引用本文： | 钟新,虞哈娜,黄清志,全贞玉.视黄醇结合蛋白4和内脂素与非酒精性脂肪肝的相关性研究[J].现代预防医学,2021,0(8):1528-1532. |
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| 作者姓名： | 钟新 虞哈娜 黄清志 全贞玉 |
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| 作者单位： | 延边大学医学院预防医学教研室，吉林 延吉 133000 |
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| 摘 要： | 目的 探讨视黄醇结合蛋白4（retinol - binding protein 4，RBP4）和内脂素与非酒精性脂肪肝（non - alcoholic fatty liver disease，NAFLD）的相关性。方法 采用2011年于某医院进行体格检查的955名年龄＞25岁成年人中身高等一般指标和谷氨酰基转移酶（γ - glutamyl transferase，GGT）等生化指标完整的780名作为研究对象。分析不同组RBP4和内脂素的血压、肝功能等指标趋势，并采用logistic回归模型分析不同RBP4和内脂素水平与NAFLD患病风险的相关性。结果 NAFLD组RBP4（t = 5.892,P＜0.001）、内脂素水平（t = 6.788,P＜0.001）均高于正常组，随着RBP4的增加，内脂素水平呈现上升趋势（P趋势＜0.001），随着内脂素的增加，RBP4水平呈现上升趋势（P趋势＜0.001），调整年龄、性别、体质指数（body mass index，BMI）、内脂素及肝功等各生化因素后，RBP4水平对NAFLD患病没有影响（OR = 1.518，95%CI:0.795～2.899）。调整年龄、性别、BMI、RBP4及肝功能等各生化因素后，内脂素仍是NAFLD的危险因子（OR = 2.268，95%CI:1.117～4.606）。结论 RBP4与NAFLD密切相关，但不是独立的危险因素。内脂素是NAFLD的独立影响因素。
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| 关 键 词： | RBP4 NAFLD 肥胖 胰岛素抵抗 内脂素 |
Correlation between retinol binding protein 4, visfatin and nonalcoholic fatty liver disease |
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| ZHONG Xin,YU Ha-na,HUANG Qing-zhi,QUAN Zhen-yu.Correlation between retinol binding protein 4, visfatin and nonalcoholic fatty liver disease[J].Modern Preventive Medicine,2021,0(8):1528-1532. |
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| Authors: | ZHONG Xin YU Ha-na HUANG Qing-zhi QUAN Zhen-yu |
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| Affiliation: | Health Toxicology of Medical College, Yanbian University, Yanji, Jilin 133000, China |
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| Abstract: | Abstract: Objective To investigate the correlation of retinol-binding protein 4 (RBP4) and visfatin and non-alcoholic with non-alcoholic fatty liver disease (NAFLD). Methods A total of 955 adults (aged >25 years) who underwent physical examination in a hospital in 2011 were included in the study, with general indicators such as height and complete biochemical indicators such as γ-Glutamyl Transferase GGT (GGT). The trends of blood pressure, liver function and other indicators of RBP4 and visfatin in different groups were analyzed. Logistic regression model was used to analyze the correlation between different RBP4 and visfatin levels and the risk of NAFLD. Results The levels of RBP4 (t=5.892, P<0.001) and visfatin (t=6.788, P<0.001) in the NAFLD group were higher than those in the normal group. With the increase ofRBP4, visfatin level showed an upward trend (Ptrend<0.001). With the increase of visfatin, the level of RBP4 showed an upward trend (Ptrend<0.001). After adjusting for various biochemical factors such as age, sex, Body Mass Index (BMI), visfatin and liver function, the level of RBP4 had no effect on the development of NAFLD (OR=1.518, 95%CI: 0.795-2.899). After adjusting for various biochemical factors such as age, sex, BMI, RBP4, and liver function, visfatin remained a risk factor for NAFLD(OR=2.268, 95% CI: 1.117 -4.606). Conclusion RBP4 is closely related to NAFLD, but not an independent risk?span>factor. Visfatin is an independent factor affecting NAFLD. |
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| Keywords: | RBP4 NAFLD Obesity Insulin resistance Visfatin |
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