骨代谢标志物在多发性骨髓瘤中的临床应用 |
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引用本文: | 翟云芝,张浩然.骨代谢标志物在多发性骨髓瘤中的临床应用[J].蚌埠医学院学报,2018,43(9):1134-1135,1139. |
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作者姓名: | 翟云芝 张浩然 |
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作者单位: | 蚌埠医学院第一附属医院 肿瘤内科, 安徽 蚌埠 233004 |
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基金项目: | 安徽省教育厅自然科学研究重点项目 |
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摘 要: | 目的:探讨多发性骨髓瘤(MM)病人血清中Ⅰ型前胶原氨基端延长肽(PINP)和Ⅰ型胶原蛋白羧基端β降解产物(β-CTX)水平及其临床意义。方法:利用电化学发光法来测定62例MM病人(MM组)和50名健康体检者(对照组)的血清PINP及β-CTX水平,比较不同临床分期的MM病人血清PINP和β-CTX水平的变化。结果:MM组病人血清PINP水平低于对照组(P<0.01),β-CTX水平高于对照组(P<0.01)。MM病人Ⅲ期β-CTX水平较Ⅰ期升高(P<0.05),Ⅱ期与Ⅰ期、Ⅲ期差异均无统计学意义(P>0.05),PINP水平在三期之间差异均无统计学意义(P>0.05)。结论:血清PINP和β-CTX水平可用于评价MM病人的骨破坏程度,β-CTX水平较PINP对MM病人的预后评价更为敏感。
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关 键 词: | 多发性骨髓瘤 骨髓瘤骨病 Ⅰ型前胶原氨基端延长肽 血清Ⅰ型胶原蛋白羧基端β降解产物 |
收稿时间: | 2018-03-16 |
Clinical application of serum bone metabolic markers in multiple myeloma |
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Affiliation: | Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China |
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Abstract: | Objective:To investigate the levels of serum β-C-terminal telopeptide of typeⅠ collagen(β-CTX) and procollagenⅠN-terminal peptide(PINP) in patients with multiple myeloma(MM),and its clinical significance.Methods:The serum levels of β-CTX and PINP in 62 MM patients(MM group) and 50 healthy people(control group) were detected using the electrochemiluminescence immunoassay.The serum levels of β-CTX and PINP in different clinical stages patients with MM were compared between two groups.Results:The serum levels of PINP and β-CTX in MM groups were lower and higher than those in control group,respectively(P<0.01).The level of β-CTX in MM patients in stage Ⅲ was higher than that in stage Ⅰ (P<0.05),there was no statistical significance in the serum level of β-CTX between stage Ⅱ and stage Ⅰ or stage Ⅲ(P>0.05),and there was no statistical significance in the serum level of PINP among stage Ⅱ,stage Ⅰ and stage Ⅲ(P>0.05).Conclusions:The serum levels of PINP and β-CTX can be used to evaluate the degree of bone destruction in patients with MM.The level of β-CTX in evaluating the prognosis of patients with MM more sensitive than that of PINP. |
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