| 三七总皂苷对心肌缺血大鼠血流动力学影响实验研究 |
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| 引用本文： | 刘杰,高秀梅,王怡,张伯礼. 三七总皂苷对心肌缺血大鼠血流动力学影响实验研究[J]. 天津中医药大学学报, 2005, 22(2): 158-160 |
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| 作者姓名： | 刘杰 高秀梅 王怡 张伯礼 |
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| 作者单位： | 天津中医学院 天津300193;天津中医学院 天津300193;天津中医学院 天津300193;天津中医学院 天津300193 |
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| 基金项目： | 国家重点基础研究发展规划“973”资助项目(1999054403) |
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| 摘 要： | [目的]探讨三七总皂苷(Panax Notoginseny Saponins,PNS)对大鼠急性心肌缺血(acute myocardial ischemia,AMI)模型血流动力学的影响。[方法]Wistar大鼠建立急性心肌缺血模型,随机分为假手术组、模型组、PNS小剂量组、PNS大剂量组。治疗7d后,分别测定左室血流动力学指标,包括左室收缩压(LVSP),左室舒张末期压(LVEDP),左室内压最大上升及下降速率(±dp/dtmax)。[结果]PNS可以降低LVEDP,升高±dp/dtmax。[结论]PNS治疗AMI可以改善心脏功能,大剂量应用对左室收缩和舒张功能均有显著提高作用。
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| 关 键 词： | 三七总皂苷 急性心肌缺血 血流动力学 |
| 收稿时间： | 2004-11-01 |
Experimental Study on Effects of Panax Notoginseny Saponins on Hemodynamics in Rats with Myocardial Ischemia |
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| LIU Jie,GAO Xiu-mei,WANG Yi. Experimental Study on Effects of Panax Notoginseny Saponins on Hemodynamics in Rats with Myocardial Ischemia[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2005, 22(2): 158-160 |
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| Authors: | LIU Jie GAO Xiu-mei WANG Yi |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | [Objective] To explore the effect of Panax Notoginseny Saponins (PNS) on the hemodynamics in rats with acute myocardial ischemia (AMI). [Methods] (AMI) was established in rats by ligature of coronary artery. They were randomly divided into sham-operated group,model group,small-dose group of PNS and large-dose group of PNS. After treatment for 7 days,the hemodynamic indexes of left ventricle (LVSP,LVEDP,±dp/dt max) were measured. [Results] PNS could reduce the LVEDP and increase the ±dp/dt max. [Conclusion] PNS can improve the cardiac function,and large-doses of PNS have marked improveing effect on systolic and diastolic function of left ventricle. |
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| Keywords: | Panax Notoginseny Saponins acute myocardial ischemia (AMI) hemodynamics |
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