Genetic vaccination against murine cysticercosis by using a plasmid vector carrying Taenia solium paramyosin |
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| Authors: | Solís Carlos F Ostoa-Saloma Pedro Lugo-Martínez Verónica H Johnston Stephen Albert Laclette Juan Pedro |
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| Affiliation: | Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, Ciudad Universitaria, C.P. 04510, México D.F., Mexico. |
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| Abstract: | A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used. |
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