Glutathione S-transferases in alcoholic liver disease |
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| Authors: | D J Harrison L May P C Hayes M M Haque J D Hayes |
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| Affiliation: | Department of Pathology, University of Edinburgh. |
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| Abstract: | There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease. |
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