沙参麦冬汤加减方联合针刺治疗LASIK术后干眼症的疗效观察

卢玉燕; 钟新娜; 易昀敏; 洪亮

沙参麦冬汤加减方联合针刺治疗LASIK术后干眼症的疗效观察

1.
浙江中医药大学附属湖州市中医院，浙江湖州 313000
2.
南昌大学附属眼科医院，江西南昌 330000
3.
江西中医药大学附属医院，江西南昌 330000

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- 刊出日期: 2019-07-10

Therapeutic Effect of Modified Shashen Maidong Decoction Combined with Acupuncture Treating Xerophthalmia After LASIK

1.
Huzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, Huzhou, 313000, China
2.
Affiliated Eye Hospital of Nanchang University, Nanchang, 330000, China
3.
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330000, China

摘要

摘要: 目的观察沙参麦冬汤加减联合针刺治疗准分子激光原位角膜磨镶术（LASIK）术后阴津不足型干眼症临床疗效。方法依据纳入和排除标准纳入有效病例60例120眼LASIK手术3月后确诊为干眼的患者，随机分为2组，各30例60只眼，对照组单纯使用人工泪液滴眼，治疗组在对照组治疗基础上加服沙参麦冬汤加减方及针刺，15 d为1个疗程，2个疗程后观察角膜荧光素染色情况（FL）情况、泪膜破裂时间（BUT）、泪液分泌试验（SIt）、裸眼视力及干眼自觉症状的改善情况。结果 2组治疗后第15天2组BUT、FL进行比较，差异无统计学意义（P>0.05）；2组SIt情况比较，治疗组优于对照组（P<0.05）。2组治疗后第30天SIt、BUT、FL、裸眼视力及自觉症状的改善治疗组均优于对照组（P<0.05）。治疗组与对照组疗程结束时症状明显改善，总有效率分别为96.8%和86.7%，有显著性差异（P<0.05）。结论中药配合针刺能有效改善LASIK术后干眼症患者的症状和体征，对治疗LASIK术后干眼症有一定优势。
- 准分子激光原位角膜磨镶术 /
- 干眼症 /
- 沙参麦冬汤加减 /
- 人工泪液 /
- 针刺
Abstract: OBJECTIVE To observe the clinical curative effect of the combination of modified Shashen Maidong decoction and acupuncture treating xerophthalmia characterized by deficiency of yin fluid after laser in situ keratomileusis (LASIK). METHODS According to inclusion and exclusion criteria， 60 effective cases were included， 120 eyes of patients diagnosed with xerophthalmia at 3 months after LASIK， which were randomly divided into two groups， 30 cases with 60 eyes respectively. The control group was treated with artificial tear drops alone while the treatment group was treated with modified Shashen Maidong decoction and acupuncture on the basis of the treatment in the control group， 15 days as a course. After two courses， we observed the corneal fluorescein staining (FL)， tear film break-up time (BUT)， Schirmer I test (SIt)， uncorrected visual acuity and the improvement of subjective symptoms. RESULTS After 15 days' treatment， the differences between BUT and FL in the two groups were not statistically significant (P>0.05). The SIt results in the two groups were compared， which showed statistically significant difference (P＜0.05) and indicated effect in the treatment group is better than that in the control group. After 30 days' treatment， compared with the control group， the treatment group was more effective in terms of SIt， BUT， FL， uncorrected visual acuity and the improvement of subjective symptoms (P＜0.05). At the end of treatment， there were obvious improvements in both two groups， 96.8% for the treatment group and 86.7% for the control group， which showed a significant difference (P＜0.05). CONCLUSION Chinese materia medica combined with acupuncture can improve the symptoms and signs of patients with xerophthalmia after LASIK and has unique therapeutic advantages.
- laser in situ<\i> keratomileusis /

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参考文献(12)

[1] 刘琳琳，曾祥云，王辉.LASIK术后干眼的临床分析[J].赣南医学院学报，2013，33(1):45-47.

[2] 杨志勇，王中林.干眼症的中医研究进展[J].光明中医，2010，4(25):738.

[3] 葛坚.眼科学[M].北京:人民卫生出版社，2005:272-274.

[4] 金明.中医临床诊疗指南释义:眼科疾病分册[M].北京:中国中医药出版社，2015:38.

[5] 中药新药临床研究指导原则[S].北京:中国医药科技出版社，2002:306-310.

[6] 李凤鸣.眼科全书:中册[M].北京:人民卫生出版社，1997:1360-1362.

[7] MELKI SA， AZAR DT. LASIK complications: etiology， management， and prevention[J]. Surv Ophthalmol， 2001，46(2): 95-116.

[8] GOTO T， ZHENG X， KLYCE SD， et al. Evaluation of the tear film stability after laser in situ<\i> keratomileusis using the tear film stability analysis system[J]. Am J Ophthalmol， 2004，137(1):116-120.

[9] SANG S， QIAN T， LI YZ. Corneal sensitivity and dry eye after LASIK[J]. Inter J Ophthalmol， 2008， 8(10): 1987-1991.

[10] KIM WS， KIM JS. Change in corneal sensitivity following laser in situ<\i> keratomileusis[J]．J Cataract Refract Surg， 1999， 25(3): 368-373.

[11] 彭胜权.温病学[M].上海:上海科学技术出版社，1996:7.

[12] 曹仁方.常见眼病针刺疗法[M].北京:人民卫生出版社，1990:16-44.

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[1]	刘琳琳，曾祥云，王辉.LASIK术后干眼的临床分析[J].赣南医学院学报，2013，33(1):45-47.
[2]	杨志勇，王中林.干眼症的中医研究进展[J].光明中医，2010，4(25):738.
[3]	葛坚.眼科学[M].北京:人民卫生出版社，2005:272-274.
[4]	金明.中医临床诊疗指南释义:眼科疾病分册[M].北京:中国中医药出版社，2015:38.
[5]	中药新药临床研究指导原则[S].北京:中国医药科技出版社，2002:306-310.
[6]	李凤鸣.眼科全书:中册[M].北京:人民卫生出版社，1997:1360-1362.
[7]	MELKI SA， AZAR DT. LASIK complications: etiology， management， and prevention[J]. Surv Ophthalmol， 2001，46(2): 95-116.
[8]	GOTO T， ZHENG X， KLYCE SD， et al. Evaluation of the tear film stability after laser in situ<\i> keratomileusis using the tear film stability analysis system[J]. Am J Ophthalmol， 2004，137(1):116-120.
[9]	SANG S， QIAN T， LI YZ. Corneal sensitivity and dry eye after LASIK[J]. Inter J Ophthalmol， 2008， 8(10): 1987-1991.
[10]	KIM WS， KIM JS. Change in corneal sensitivity following laser in situ<\i> keratomileusis[J]．J Cataract Refract Surg， 1999， 25(3): 368-373.
[11]	彭胜权.温病学[M].上海:上海科学技术出版社，1996:7.
[12]	曹仁方.常见眼病针刺疗法[M].北京:人民卫生出版社，1990:16-44.

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沙参麦冬汤加减方联合针刺治疗LASIK术后干眼症的疗效观察

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出版历程

Therapeutic Effect of Modified Shashen Maidong Decoction Combined with Acupuncture Treating Xerophthalmia After LASIK

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出版历程

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