复方银杏叶制剂配伍减毒初步研究
Toxin Attenuation Effect of Compound Folium Ginkgo Preparations
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摘要: 目的考察复方银杏叶制剂配伍减毒作用。方法观察不同比例刺梨汁粉与银杏叶提取物配伍的小鼠急性毒性及复方银杏叶制剂的LD50。结果银杏叶提取物与刺梨汁粉以1∶1.5比例配伍组的小鼠急性毒性最低。复方银杏叶制剂LD50>10 000 mg/kg。结论刺梨与银杏叶提取物配伍可提高制剂的安全性。
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Key words:
- Folium Ginkgo /
- Grossularia burejensis Berger /
- ginkgolic acid /
- toxicity
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[1] Braquet P.The ginkgolides:potent platelet activating factor antagonists isolated from ginkgo biloba L[J].Drugs of the Future,1987,12(7):643. [2] Koch E,Jaggy H,Chatterjee SS.Evidence for immunotoxic effects of crude Ginkgo biloba L.leaf extracts using the popliteal lymph node assay in the mouse[J].Int J Immunopharmacol,2000,22:229. [3] Hecker H,Johannisson R,Koch E,et al.In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L.[J].Toxicology,2002,177:167. [4] 仰榴青,吴向阳,杨克迪,等.银杏酸分析方法研究进展[J].药物分析杂志,2003,23(3):241.
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