Abstract: | Fifteen hybrid rats divided int0 3 groups (A,
B and C) were fed for 250 days with distilled,
50 ppm and 80 ppm NaF water respectively. Before
exsanguination, doubled tetracycline labelings were
made on all of the experimental animals for bone
dynamic study. The available data suggest that the
primary mineralization and matrix synthesis in group
B and C were significantly inhibited, indicating the
toxic effects of high fluoride on osteoblasts. For
a better understanding of the pathogenesis of osteos
clerosis, osteomalacia and osteoporosis in endemic
fluorosis, we wou.lld suggest that fluoride be used
not only as a stimulator for bone formation as is
being recommended in the treatment of postmeno
pausal ostcoporosis accompanied somewhat by
osteosclerosis, but also as an inhibitor for matrix
synthesis and primary mineralization through its
toxic effects on osteoblast. We believe that the
pathology of fluorosis depends largely on the dose
of fluoride intake. |