持续气道正压通气对合并2型糖尿病的OSAHS患者胰岛素抵抗的影响
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Effects of continuous positive airway pressure treatment on insulin resistance in patients with type 2 diabetes and obstructive sleep apnea hypopnea syndrome
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    摘要:

    目的:通过观察了持续气道正压通气(CPAP)治疗对合并2型-糖尿病(2型-DM)的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的胰岛素抵抗(IR)的影响, 以验证OSAHS是否为引起糖尿病患者IR增加的独立危险因素。方法:选择25例合并2型-DM的肥胖OSAHS患者,将他们的呼吸暂停/低通气指数(AHI)为37.7 ± 18.0;体重指数(BMI)被控制在29.1 ± 2.3 kg/m2;通过6个月的CPAP治疗观察治疗前后反映IR的稳态模式评估(HOMA)指数变化。结果:在BMI无明显改变的情况下,6个月的CPAP治疗后HOMA指数较治疗前明显降低(1.84 ± 1.98 vs 3.33 ± 2.96, P < 0.0001)。结论:CPAP治疗可显著改善OSAHS患者的IR增高,提示OSAHS是IR的独立危险因素。

    Abstract:

    Objective: To investigate the effects of continuous positive airway pressure(CPAP) treatment on insulin resistance (IR) in patients with type 2 diabetes and obstructive sleep apnea hypopnea syndrome(OSAHS). Methods:Twenty-five patients with type 2 diabetes and OSAHS were recruited. Their apnea hypopnea index (AHI) was 37.7±18.0 with BMI maintained at 29.1 ± 2.3 kg/m2. The homeostasis model assessment(HOMA) index was used to reflect IR and measured before and after 6 months’ CPAP treatment. Results:The HOMA index was significantly lower following 6 months’ CPAP treatment than before treatment(1.84 ± 1.98 vs 3.33 ± 2.96, P < 0.0001). Conclusion:CPAP treatment can significantly improved increased IR in OSAHS patients, which suggests that OSAS is an independent risk factor of IR.

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李 翀.持续气道正压通气对合并2型糖尿病的OSAHS患者胰岛素抵抗的影响[J].南京医科大学学报(自然科学版),2007,(1):39-42

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  • 收稿日期:2006-08-09
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  • 在线发布日期: 2007-01-15
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