Using a serum pharmacological method that the sera,derived from the rats orally taking FZHY,were incubated with culturd ito cells(Fat-storing cells,passage 1) of the rats,it wasinvestigated that FZHY affected ito cell functions such a cell proliferation and collagen synthesi.The results showed that the FZHY sera had no cytotoxicity towards the ito cells inhibited cell proliferation and collagen synthesis.Furthermore,this inhibition had a positive relation with administration and dosage of the FZHYdecoction bood-taken tine,and the concentration of the sera in the culture,was concluded that the inhibition of FZHY on ito cells may be one of mechanisms through which liver fibrosis was prevented with it.