Objective:To observe the function of decreasing blood-lipid by extract from Flos carthami in rat with hyperlipidemia and safety of water extract.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage,the levels of TC,TG,HDL,LDL were assayed;actue toxicity test and thirty days feeding study were employed.Results:The levels of TG,TC,LDL-C in all groups treated with the water extract of Flos Carthami were significantly reduced.The alcohol extract of Flos carthami showed a decreased action for TC.For safety,water extract showed no death nor toxic symptom.All the observed index showed no relationship between postponing time and increasing doses during 30 d feeding period.And in teratogenicity tests,pregnant rats grew well;fetuses developed naturally,and the ratio of abnormal fetues was in the range of natural abnormal ratio.Conclusions:The extract of Flos carthami indicaterd the function of decreasing the blood-lipid,and no obvious toxic effects have been observed.